Isolation and differential secretion of metalloproteinase by superficial chondrocytes in articular cartilage

被引：7

作者：

Takagi, T ^{[1
]}

Takahashi, S ^{[1
]}

Koshino, T ^{[1
]}

Okamoto, R ^{[1
]}

Jasin, HE ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Orthopaed Surg, Sch Med, Kanazawa Ku, Yokohama, Kanagawa 236, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 1998年 / 22卷 / 01期

关键词：

D O I：

10.1007/s002640050208

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Chondrocytes from superficial layers of articular cartilage have distinct phenotypic properties which are different from those of cells obtained from the deeper areas. We describe a method that isolates highly purified articular cartilage chondrocytes from the superficial layers, When the superficial cells are stimulated in vitro with a source of cytokines, they secrete greater amounts of metalloproteinase compared to chondrocytes obtained from a deeper area.

引用

页码：55 / 58

页数：4

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