Role of endothelin-1 in hypertension

被引：62
作者：
Iglarz, M [1 ]
Schiffrin, EL [1 ]
机构：
[1] Clin Res Inst Montreal, Montreal, PQ H2W 1R7, Canada
来源：
CURRENT HYPERTENSION REPORTS | 2003年 / 5卷 / 02期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1007/s11906-003-0071-4
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is overexpressed in the vasculature in different models of hypertension, such as deoxycorticosterone acetate-salt rats, Dahl salt-sensitive rats, and stroke-prone spontaneously hypertensive rats. Moreover, patients with moderate to severe hypertension present increased vascular levels of prepro-ET-1 mRNA. In addition to their blood pressure-lowering effects, ET receptor antagonists are able to reduce vascular growth. Recent data suggest the involvement of an inflammatory response in the effects of ET-1, which contributes to vascular remodeling and endothelial dysfunction. Increasing evidence underscores the potential therapeutic benefit of ET receptor antagonists in different hypertension-related complications, not only in essential hypertension, but also in patients with type 2 diabetes.
引用
收藏
页码：144 / 148
页数：5
相关论文
共 51 条
[31]   Effect of bosentan on NF-κB, inflammation, and tissue factor in angiotensin II-induced end-organ damage [J].
Muller, DN ;
Mervaala, EMA ;
Schmidt, F ;
Park, JK ;
Dechend, R ;
Genersch, E ;
Breu, V ;
Löffler, BM ;
Ganten, D ;
Schneider, W ;
Haller, H ;
Luft, FC .
HYPERTENSION, 2000, 36 (02) :282-290
[32]   Darusentan:: An effective endothelinA receptor antagonist for treatment of hypertension [J].
Nakov, R ;
Pfarr, E ;
Eberle, S .
AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (07) :583-589
[33]   Permissive role of nitric oxide in endothelin-induced migration of endothelial cells [J].
Noiri, E ;
Hu, Y ;
Bahou, WF ;
Keese, CR ;
Giaever, I ;
Goligorsky, MS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (03) :1747-1752
[34]   ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats [J].
Park, JB ;
Schiffrin, EL .
HYPERTENSION, 2001, 37 (06) :1444-1449
[35]   Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats [J].
Park, JB ;
Touyz, RM ;
Chen, X ;
Schiffrin, EL .
AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (01) :78-84
[36]   Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: Role of endothelin-1 [J].
Park, JB ;
Schiffrin, EL .
AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (02) :164-169
[37]   Endothelin inhibits thick ascending limb chloride flux via ETB receptor-mediated NO release [J].
Plato, CF ;
Pollock, DM ;
Garvin, JL .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (02) :F326-F333
[38]   Leptin induces endothelin-1 in endothelial cells in vitro [J].
Quehenberger, P ;
Exner, M ;
Sunder-Plassmann, R ;
Ruzicka, K ;
Bieglmayer, C ;
Endler, G ;
Muellner, C ;
Speiser, W ;
Wagner, O .
CIRCULATION RESEARCH, 2002, 90 (06) :711-718
[39]   Bosentan therapy for pulmonary arterial hypertension [J].
Rubin, LJ ;
Badesch, DB ;
Barst, RJ ;
Galiè, N ;
Black, CM ;
Keogh, A ;
Pulido, T ;
Frost, A ;
Roux, S ;
Leconte, I ;
Landzberg, M ;
Simonneau, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (12) :896-903
[40]   Renal endothelin in chronic angiotensin II hypertension [J].
Sasser, JM ;
Pollock, JS ;
Pollock, DM .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2002, 283 (01) :R243-R248
123456