The Human Vaccines Project: A roadmap for cancer vaccine development

被引：172

作者：

Romero, Pedro ^{[1
]}

Banchereau, Jacques ^{[2
]}

Bhardwaj, Nina ^{[3
]}

Cockett, Mark ^{[4
,29
]}

Disis, Mary L. ^{[5
]}

Dranoff, Glenn ^{[6
]}

Gilboa, Eli ^{[7
]}

Hammond, Scott A. ^{[8
]}

Hershberg, Robert ^{[9
]}

Korman, Alan J. ^{[10
]}

Kvistborg, Pia ^{[11
]}

Melief, Cornelis ^{[12
,13
]}

Mellman, Ira ^{[14
]}

Palucka, A. Karolina ^{[2
,15
]}

Redchenko, Irina ^{[16
]}

Robins, Harlan ^{[17
]}

Sallusto, Federica ^{[18
]}

Schenkelberg, Theodore ^{[19
]}

Schoenberger, Stephen ^{[20
,21
]}

Sosman, Jeffrey ^{[22
,23
]}

Tuereci, Oezlem ^{[24
]}

Van den Eynde, Benoit ^{[25
,26
,27
]}

Koff, Wayne ^{[28
]}

Coukos, George ^{[1
]}

机构：

[1] Univ Lausanne, Ludwig Canc Res, CH-1066 Epalinges, Switzerland

[2] Jackson Lab Genom Med, Farmington, CT 06032 USA

[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[4] Bristol Myers Squibb Co, 5 Res Pkwy, Wallingford, CT 06492 USA

[5] Univ Washington, Sch Med, Seattle, WA 98109 USA

[6] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

[7] Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[8] Medimmune Inc, Gaithersburg, MD 20878 USA

[9] Celgene Immunooncol Ctr Excellence, 1616 Eastlake Ave,Suite 500, Seattle, WA 98102 USA

[10] Bristol Myers Squibb, Biol Discovery Calif, Redwood City, CA 94063 USA

[11] Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[12] ISA Pharmaceut, NL-2333 ZA Leiden, Netherlands

[13] Leiden Univ, Med Ctr, NL-2333 ZA Leiden, Netherlands

[14] Genentech Inc, San Francisco, CA 94080 USA

[15] Baylor Inst Immunol Res, Dallas, TX 75204 USA

[16] Univ Oxford, Oxford OX3 7DQ, England

[17] Fred Hutchinson Canc Res Ctr, Adapt Biotechnol, Seattle, WA 98102 USA

[18] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[19] West Monument Consulting, 1906 R St NW St 11, Washington, DC 20009 USA

[20] La Jolla Inst Allergy & Immunol, Ctr Personalized Canc Immunotherapy, San Diego, CA 92037 USA

[21] UCSD Moores Canc Ctr, San Diego, CA 92037 USA

[22] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

[23] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[24] CI3 Cluster Individualized Immunotherapy, Kupferbergterasse 17-19, D-55131 Mainz, Germany

[25] Ludwig Inst Canc Res, Brussels Branch, BRU-1200 Brussels, Belgium

[26] Catholic Univ Louvain, Ave Hippocrate 10, B-1200 Woluwe St Lambert, Belgium

[27] Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Med, Old Rd Campus Res Bldg, Oxford OX3 7DQ, England

[28] Int AIDS Vaccines Initiat, 125 Broad St,9th Floor, New York, NY 10004 USA

[29] ViiV Healthcare, 5 Res Pkwy, Wallingford, CT 06492 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 334期

关键词：

T-CELL DIFFERENTIATION; RANDOMIZED CONTROLLED-TRIAL; DENDRITIC CELLS; LUNG-CANCER; INTRAEPITHELIAL NEOPLASIA; THERAPEUTIC VACCINES; CHECKPOINT BLOCKADE; IMMUNE-RESPONSE; PROSTATE-CANCER; IMMUNOTHERAPY;

D O I：

10.1126/scitranslmed.aaf0685

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

引用

页数：7

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