A common allele on chromosome 9 associated with coronary heart disease

被引：1364

作者：

McPherson, Ruth

Pertsemlidis, Alexander

Kavaslar, Nihan

Stewart, Alexandre F. R.

Roberts, Robert

Cox, David R.

Hinds, David A.

Pennacchio, Len A.

Tybjaerg-Hansen, Anne

Folsom, Aaron R.

Boerwinkle, Eric

Hobbs, Helen H.

Cohen, Jonathan C. ^{[1
]}

机构：

[1] Univ Ottawa, Inst Heart, Div Cardiol, Ottawa, ON K1Y 4W7, Canada

[2] Univ Texas, SW Med Ctr, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[4] Perlegen Sci, Mountain View, CA 94043 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Genom Div, Berkeley, CA 94720 USA

[6] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[7] Univ Copenhagen Hosp, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark

[8] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA

[9] Univ Texas, Hlth Sci Ctr, Ctr Human Genet, Houston, TX 77030 USA

[10] Univ Texas, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA

[11] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

[12] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA

来源：

SCIENCE | 2007年 / 316卷 / 5830期

关键词：

D O I：

10.1126/science.1142447

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coronary heart disease ( CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples ( more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a similar to 30 to 40% increased risk of CHD.

引用

页码：1488 / 1491

页数：4

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