The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells

被引：34
作者：
Kim, Taejung [1 ]
Kim, Young-Joo [1 ]
Han, Im-Ho [1 ]
Lee, Dahae [1 ,2 ]
Ham, Jungyeob [1 ]
Kang, Ki Sung [2 ]
Lee, Jae Wook [1 ,3 ]
机构：
[1] Korea Inst Sci & Technol, Nat Prod Res Ctr, Kangnung 210340, South Korea
[2] Gachon Univ, Coll Korean Med, Songnam 461701, South Korea
[3] Univ Sci & Technol, Dept Biol Chem, Taejon 305350, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 01期
关键词：
Sulforaphane; Cisplatin induced kidney disease; Kidney protection; Reactive oxygen species; Isothiocyanate; INDUCED APOPTOSIS; IN-VITRO; MOLECULAR-BASIS; LLC-PK1; CELLS; DNA-DAMAGE; ACTIVATION; INDUCTION; MOUSE; P53; CHEMOPREVENTION;
D O I：
10.1016/j.bmcl.2014.11.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc(2)O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 mu M. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：62 / 66
页数：5
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