Epigenetic mechanisms that regulate antigen receptor gene expression

被引：33
作者：
Bergman, Y
Fisher, A
Cedar, H
机构：
[1] Hebrew Univ Jerusalem, Dept Expt Med & Canc Res, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Dept Cellular Biochem & Human Genet, IL-91120 Jerusalem, Israel
[3] Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, Med Res Council Clin Sci Ctr, Fac Med, London W12 ONN, England
来源：
CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 02期
关键词：
D O I：
10.1016/S0952-7915(03)00016-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Functional immunoglobulin and T-cell receptor genes are generated from germline V, D and J gene segments by a series of site-specific recombination events. This process is regulated by the availability of recombination machinery and by the ordered accessibility of appropriate target gene segments. Recent studies highlight the importance of chromatin remodelling and locus positioning for controlling antigen receptor gene expression and recombination.
引用
收藏
页码：176 / 181
页数：6
相关论文
共 58 条
[1]   Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination [J].
Agata, Y ;
Katakai, T ;
Ye, SK ;
Sugai, M ;
Gonda, H ;
Honjo, T ;
Ikuta, K ;
Shimizu, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (07) :873-879
[2]   Spacial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type-specific organizational patterns [J].
Alcobia, I ;
Dilao, R ;
Parreira, L .
BLOOD, 2000, 95 (05) :1608-1615
[3]   Developmentally programmed rearrangement of T cell receptor Vγ genes is controlled by sequences immediately upstream of the Vγ genes [J].
Baker, JE ;
Cado, D ;
Raulet, DH .
IMMUNITY, 1998, 9 (02) :159-168
[4]   The mechanism and regulation of chromosomal V(D)J recombination [J].
Bassing, CH ;
Swat, W ;
Alt, FW .
CELL, 2002, 109 :S45-S55
[5]   Transcription factor NF-κB regulates Igλ light chain gene rearrangement [J].
Bendall, HH ;
Sikes, ML ;
Oltz, EM .
JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :264-269
[6]  
Bergman Y, 1998, BIOL CHEM, V379, P401
[7]   Allelic exclusion in B and T lymphopoiesis [J].
Bergman, Y .
SEMINARS IN IMMUNOLOGY, 1999, 11 (05) :319-328
[8]   Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division [J].
Brown, KE ;
Baxter, J ;
Graf, D ;
Merkenschlager, M ;
Fisher, AG .
MOLECULAR CELL, 1999, 3 (02) :207-217
[9]   Retroviral expression in embryonic stem cells and hematopoietic stem cells [J].
Cherry, SR ;
Biniszkiewicz, D ;
van Parijs, L ;
Baltimore, D ;
Jaenisch, R .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (20) :7419-7426
[10]   Chromatin remodeling directly activates V(D)J recombination [J].
Cherry, SR ;
Baltimore, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10788-10793
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