QacA multidrug efflux pump from Staphylococcus aureus:: Comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones

被引：2
|
作者：
Mitchell, BA [1 ]
Brown, MH [1 ]
Skurray, RA [1 ]
机构：
[1] Univ Sydney, Sch Biol Sci A12, Sydney, NSW 2006, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.
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页码：475 / 477
页数：3
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