Comparison of SimoaTM and EllaTM to assess serum neurofilament-light chain in multiple sclerosis

被引：68

作者：

Gauthier, Audrey ^{[1
]}

Viel, Sebastien ^{[2
,3
]}

Perret, Magali ^{[2
]}

Brocard, Guillaume ^{[4
,5
,6
,7
,8
]}

Casey, Romain ^{[4
,5
,6
,7
,8
]}

Lombard, Christine ^{[2
]}

Laurent-Chabalier, Sabine ^{[9
]}

Debouverie, Marc ^{[10
,11
]}

Edan, Gilles ^{[12
]}

Vukusic, Sandra ^{[4
,5
,6
,7
,8
]}

Lebrun-Frenay, Christine ^{[13
]}

De Seze, Jerome ^{[14
,15
]}

Laplaud, David Axel ^{[16
,17
,18
]}

Castelnovo, Giovanni ^{[19
]}

Gout, Olivier ^{[20
]}

Ruet, Aurelie ^{[21
,22
,23
]}

Moreau, Thibault ^{[24
]}

Casez, Olivier ^{[25
]}

Clavelou, Pierre ^{[26
,27
]}

Berger, Eric ^{[28
]}

Zephir, Helene ^{[29
]}

Trouillet-Assant, Sophie ^{[3
,30
]}

Thouvenot, Eric ^{[19
,31
]}

机构：

[1] Ecole Prat Hautes Etud, Paris Sci & Lettres, Paris, France

[2] Lyon Sud Hosp, Hosp Civils Lyon, Immunol Lab, Pierre Benite, France

[3] Lyon Univ, UCBL, CNRS, Int Ctr Res Infectiol,INSERM,U1111,UMR 5308,ENS, Lyon, France

[4] Univ Claude Bernard Lyon 1, Univ Lyon, F-69000 Lyon, France

[5] Hosp Civils Lyon, Serv Neurol, Sclerose Plaques Pathol Myeline & Neuroinflammat, F-69677 Bron, France

[6] Ctr Rech Neurosci Lyon, INSERM 1028, Observ Francais Sclerose Plaques, F-69003 Lyon, France

[7] CNRS, UMR 5292, F-69003 Lyon, France

[8] EUGENE DEVIC EDMUS Fdn Multiple Sclerosis, State Approved Fdn, F-69677 Bron, France

[9] Univ Montpellier, CHU Nimes, Dept Biostat Clin Epidemiol Publ Hlth & Innovat M, Nimes, France

[10] Nancy Univ Hosp, Dept Neurol, Nancy, France

[11] Univ Lorraine, APEMAC, F-54000 Nancy, France

[12] CHU Pontchaillou, INSERM, CIC1414, F-35000 Rennes, France

[13] Univ Nice Cote Azur, CHU Pasteur2, CRCSEP, Dept Neurol,UR2CA,URRIS, Nice, France

[14] CHU Strasbourg, INSERM 1434, CIC 1434, Dept Neurol, F-67000 Strasbourg, France

[15] CHU Strasbourg, Clin Invest Ctr, INSERM 1434, CIC 1434, F-67000 Strasbourg, France

[16] CHU Nantes, Dept Neurol, F-44093 Nantes, France

[17] CHU Nantes, INSERM, CIC015, F-44093 Nantes, France

[18] INSERM, U1064, CRTI, F-44000 Nantes, France

[19] Univ Montpellier, CHU Nimes, Dept Neurol, Nimes, France

[20] Fdn Adolphe De Rothschild, Dept Neurol, F-75000 Paris, France

[21] Univ Bordeaux, F-33000 Bordeaux, France

[22] Neuroctr Magendie, INSERM, U1215, Bordeaux, France

[23] CHU Bordeaux, CIC Bordeaux, CIC1401, Dept Neurol, F-33000 Bordeaux, France

[24] CHU Dijon, EA4184, Dept Neurol, F-21000 Dijon, France

[25] CHU Grenoble Alpes, Dept Neurol, F-38700 La Tronche, France

[26] CHU Clermont Ferrand, Dept Neurol, F-63000 Clermont Ferrand, France

[27] Univ Clermont Auvergne, INSERM, Neurodol, F-63000 Clermont Ferrand, France

[28] CHU Besancon, Dept Neurol, F-25030 Besancon, France

[29] Univ Lille, CHU Lille, CRCSEP Lille, U1172, F-59000 Lille, France

[30] Lyon Sud Hosp, Pierre Benite, France

[31] Univ Montpellier, CNRS, INSERM, Inst Genom Fonct, F-34094 Montpellier 5, France

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2021年 / 8卷 / 05期

关键词：

D O I：

10.1002/acn3.51355

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared Simoa(TM) and Ella(TM) immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (rho = 0.86, p < 0.0001) between both platforms. The Ella(TM) instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella(TM) results. As for Simoa(TM), serum neurofilament-light chain levels measured by Ella(TM) were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.

引用

页码：1141 / 1150

页数：10

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