Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle Dysfunction

被引：20

作者：

Haberman, Dan ^{[1
]}

Estevez-Loureiro, Rodrigo ^{[2
]}

Benito-Gonzalez, Tomas ^{[3
]}

Denti, Paolo ^{[4
]}

Arzamendi, Dabit ^{[5
]}

Adamo, Marianna ^{[6
]}

Freixa, Xavier ^{[7
]}

Nombela-Franco, Luis ^{[8
]}

Villablanca, Pedro ^{[9
]}

Krivoshei, Lian ^{[10
]}

Fam, Neil ^{[11
]}

Spargias, Konstantinos ^{[12
]}

Czarnecki, Andrew ^{[13
]}

Pascual, Isaac ^{[14
]}

Praz, Fabien ^{[15
]}

Sudarsky, Doron ^{[16
]}

Kerner, Arthur ^{[17
,18
]}

Ninios, Vlasis ^{[19
]}

Gennari, Marco ^{[20
,21
]}

Beeri, Ronen ^{[22
]}

Perl, Leor ^{[23
,24
]}

Danenberg, Haim ^{[22
]}

Poles, Lion ^{[1
]}

Shimoni, Sara ^{[1
]}

Goland, Sorel ^{[1
]}

Caneiro-Queija, Berenice ^{[2
]}

Scianna, Salvatore ^{[21
]}

Moaraf, Igal ^{[10
]}

Schiavi, Davide ^{[4
]}

Scardino, Claudia ^{[25
]}

Corpataux, Noe ^{[15
]}

Echarte-Morales, Julio ^{[3
]}

Chrissoheris, Michael ^{[12
]}

Fernandez-Peregrina, Estefania ^{[5
]}

Di Pasquale, Mattia ^{[6
]}

Regueiro, Ander ^{[7
]}

Vergara-Uzcategui, Carlos ^{[8
]}

Iniguez-Romo, Andres ^{[2
]}

Fernandez-Vazquez, Felipe ^{[3
]}

Dvir, Danny ^{[26
]}

Taramasso, Maurizio ^{[21
]}

Shuvy, Mony ^{[22
,26
]}

机构：

[1] Hebrew Univ Jerusalem, Ctr Heart, Kaplan Med Ctr, IL-9190501 Jerusalem, Israel

[2] Hosp Alvaro Cunqueiro, Intervent Cardiol Unit, Vigo 36321, Spain

[3] Complejo Asistencial Univ Leon, Intervent Cardiol Unit, Leon 24071, Spain

[4] San Raffaele Univ Hosp, Cardiovasc Surg Dept, I-20132 Milan, Italy

[5] Hosp St Pau & Santa Creu, Intervent Cardiol Unit, Barcelona 08041, Spain

[6] ASST Spedali Civili Brescia, Cardiac Catheterizat Lab, I-25123 Brescia, Italy

[7] Hosp Clin Barcelona, Intervent Cardiol Unit, Barcelona 08036, Spain

[8] IdISSC, Inst Invest Sanitaria San Carlos, Hosp Clin San Carlos, Madrid 28040, Spain

[9] Henry Ford Hosp, Intervent Cardiol, Ctr Struct Heart Dis, Detroit, MI 48202 USA

[10] Kantonsspital Baden, Dept Cardiol, CH-5404 Baden, Switzerland

[11] Univ Toronto, St Michaels Hosp, Div Cardiol, Toronto, ON M5B 1W8, Canada

[12] HYGEIA Hosp, Dept Transcatheter Heart Valves, Athens 15123, Greece

[13] Univ Toronto, Schulich Heart Ctr, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[14] Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain

[15] Univ Bern, Univ Hosp Bern, Inselspital, CH-3010 Bern, Switzerland

[16] Baruch Padeh Med Ctr, Cardiovasc Inst, IL-1520800 Poriya, Israel

[17] Technion Med Sch, Dept Cardiol, Rambam Med Ctr, IL-3109601 Haifa, Israel

[18] Technion Med Sch, B Rappaport Fac Med, IL-3109601 Haifa, Israel

[19] Interbalkan European Med Ctr, Dept Cardiol, Thessaloniki 55535, Greece

[20] IRCCS Ctr Cardiol Monzino, Dept Cardiovasc Surg, I-20138 Milan, Italy

[21] Univ Hosp Zurich, Heart Valve Clin, CH-8006 Zurich, Switzerland

[22] Hadassah Hebrew Univ Med Ctr, Inst Heart, IL-91120 Jerusalem, Israel

[23] Tel Aviv Univ, Dept Cardiol, Rabin Med Ctr, IL-49100 Tel Aviv, Israel

[24] Tel Aviv Univ, Sackler Fac Med, IL-49100 Tel Aviv, Israel

[25] Joan XXIII Univ Hosp, Dept Cardiol, Tarragona 43005, Spain

[26] Hebrew Univ Jerusalem, Shaare Zedek Med Ctr, Jesselson Integrated Heart Ctr, IL-9103102 Jerusalem, Israel

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 09期

关键词：

mitral regurgitation; percutaneous mitral valve repair; acute myocardial infarction; left ventricle dysfunction; VALVE REPAIR; AMERICAN SOCIETY; PROGNOSTIC VALUE; ECHOCARDIOGRAPHY; RECOMMENDATIONS; ASSOCIATION; GUIDELINES; OUTCOMES; REGISTRY;

D O I：

10.3390/jcm10091819

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)-35%. Included in the study were 105 patients. The mean age was 71 +/- 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.

引用

页数：14

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