The Role of Neurodevelopmental Pathways in Brain Tumors

被引：38

作者：

Curry, Rachel N. ^{[1
,2
]}

Glasgow, Stacey M. ^{[3
,4
,5
]}

机构：

[1] Baylor Coll Med, Ctr Cell & Gene Therapy Houston, Dept Neurosci, Houston, TX 77030 USA

[2] Baylor Coll Med, Integrat Mol & Biomed Sci, Grad Sch Biomed Sci, Houston, TX 77030 USA

[3] Univ Calif San Diego, Neurobiol Sect, Div Biol Sci, San Diego, CA 92103 USA

[4] Univ Calif San Diego, Neurosci Grad Program, San Diego, CA 92103 USA

[5] Univ Calif San Diego, Biomed Sci Grad Program, San Diego, CA 92103 USA

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

美国国家卫生研究院;

关键词：

neurodevelopment; brain tumors; glioma; transcription factor; signaling pathway; CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; INTEGRATED GENOMIC ANALYSIS; GLIOMA-INITIATING CELLS; GROWTH-FACTOR RECEPTOR; TRANS-RETINOIC ACID; TGF-BETA; TRANSCRIPTION FACTORS; PAX GENES; UP-REGULATION;

D O I：

10.3389/fcell.2021.659055

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Disruptions to developmental cell signaling pathways and transcriptional cascades have been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant neurodevelopmental programs in the context of brain tumors highlights the numerous parallels that exist between developmental and oncologic mechanisms. A deeper understanding of how dysregulated developmental factors contribute to brain tumor oncogenesis and disease progression will help to identify potential therapeutic targets for these malignancies. In this review, we summarize the current literature concerning developmental signaling cascades and neurodevelopmentally-regulated transcriptional programs. We also examine their respective contributions towards tumor initiation, maintenance, and progression in both pediatric and adult brain tumors and highlight relevant differentiation therapies and putative candidates for prospective treatments.

引用

页数：27

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