The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival

被引:11
作者
Paiardi, Chiara [1 ]
Mirzoyan, Zhasmine [1 ]
Zola, Sheri [2 ]
Parisi, Federica [3 ]
Vingiani, Andrea [4 ]
Pasini, Maria Enrica [1 ]
Bellosta, Paola [1 ,2 ]
机构
[1] Univ Milan, Dept Biosci, Via Celoria 26, I-20133 Milan, Italy
[2] Univ Trento, Ctr Integrated Biol CiBio, Via Sommar 9, I-38123 Trento, Italy
[3] Crown Biosci Inc, Santa Clara, CA USA
[4] European Inst Oncol IEO, Dept Pathol, Via Ripamonti 435, I-20100 Milan, Italy
来源
GENES | 2017年 / 8卷 / 05期
基金
美国国家卫生研究院;
关键词
Myc; SCD-1/Desat1; autophagy; growth; lipid metabolism; prostate tumors; Drosophila; STARVATION-INDUCED AUTOPHAGY; CANCER METABOLISM; CELL COMPETITION; BREAST-CANCER; PROTEIN; INHIBITION; EXPRESSION; INSULIN; DEATH; FAT;
D O I
10.3390/genes8050131
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Lipids are an important energy supply in our cells and can be stored or used to produce macromolecules during lipogenesis when cells experience nutrient starvation. Our proteomic analysis reveals that the Drosophila homologue of human Stearoyl-CoA desaturase-1 (Desat1) is an indirect target of Myc in fat cells. Stearoyl-CoA desaturases are key enzymes in the synthesis of monounsaturated fatty acids critical for the formation of complex lipids such as triglycerides and phospholipids. Their function is fundamental for cellular physiology, however in tumors, overexpression of SCD-1 and SCD-5 has been found frequently associated with a poor prognosis. Another gene that is often upregulated in tumors is the proto-oncogene c-myc, where its overexpression or increased protein stability, favor cellular growth. Here, we report a potential link between Myc and Desat1 to control autophagy and growth. Using Drosophila, we found that expression of Desat1, in metabolic tissues like the fat body, in the gut and in epithelial cells, is necessary for Myc function to induce autophagy a cell eating mechanism important for energy production. In addition, we observed that reduction of Desat1 affects Myc ability to induce growth in epithelial cells. Our data also identify, in prostatic tumor cells, a significant correlation between the expression of Myc and SCD-1 proteins, suggesting the existence of a potential functional relationship between the activities of these proteins in sustaining tumor progression.
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页数:14
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