Lipids are an important energy supply in our cells and can be stored or used to produce macromolecules during lipogenesis when cells experience nutrient starvation. Our proteomic analysis reveals that the Drosophila homologue of human Stearoyl-CoA desaturase-1 (Desat1) is an indirect target of Myc in fat cells. Stearoyl-CoA desaturases are key enzymes in the synthesis of monounsaturated fatty acids critical for the formation of complex lipids such as triglycerides and phospholipids. Their function is fundamental for cellular physiology, however in tumors, overexpression of SCD-1 and SCD-5 has been found frequently associated with a poor prognosis. Another gene that is often upregulated in tumors is the proto-oncogene c-myc, where its overexpression or increased protein stability, favor cellular growth. Here, we report a potential link between Myc and Desat1 to control autophagy and growth. Using Drosophila, we found that expression of Desat1, in metabolic tissues like the fat body, in the gut and in epithelial cells, is necessary for Myc function to induce autophagy a cell eating mechanism important for energy production. In addition, we observed that reduction of Desat1 affects Myc ability to induce growth in epithelial cells. Our data also identify, in prostatic tumor cells, a significant correlation between the expression of Myc and SCD-1 proteins, suggesting the existence of a potential functional relationship between the activities of these proteins in sustaining tumor progression.
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Baenke, Franziska
Peck, Barrie
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Peck, Barrie
Miess, Heike
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Miess, Heike
Schulze, Almut
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
de la Cova, Claire
Senoo-Matsuda, Nanami
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Waseda Univ, Sch Adv Sci & Engn, Dept Life Sci & Med BioSci, Shinjuku Ku, Tokyo 1628480, JapanColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Senoo-Matsuda, Nanami
Ziosi, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Univ Bologna, Dept Expt Pathol, I-40126 Bologna, ItalyColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Ziosi, Marcello
Wu, D. Christine
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Wu, D. Christine
Bellosta, Paola
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Bellosta, Paola
Quinzii, Catarina M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Quinzii, Catarina M.
Johnston, Laura A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
机构:
Univ Modena, Dept Med Sci, I-41100 Modena, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Galletti, Margherita
Riccardo, Sara
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Riccardo, Sara
Parisi, Federica
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USA
Alma Mater Studiorum, Dept Expt Pathol, Bologna, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Parisi, Federica
Lora, Carlina
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Lora, Carlina
Saqcena, Mahesh Kumar
论文数: 0引用数: 0
h-index: 0
机构:
CUNY, Queens Coll, Dept Chem & Biochem, New York, NY USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Saqcena, Mahesh Kumar
Rivas, Leinny
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Rivas, Leinny
Wong, Bonnie
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Wong, Bonnie
Serra, Alexis
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Serra, Alexis
Serras, Florenci
论文数: 0引用数: 0
h-index: 0
机构:
Univ Barcelona, Dept Genet, Barcelona, SpainCUNY City Coll, Dept Biol, New York, NY 10031 USA
Serras, Florenci
Grifoni, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Alma Mater Studiorum, Dept Expt Pathol, Bologna, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Grifoni, Daniela
Pelicci, PierGiuseppe
论文数: 0引用数: 0
h-index: 0
机构:
European Inst Oncol, Milan, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Pelicci, PierGiuseppe
Jiang, Jin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Jiang, Jin
Bellosta, Paola
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Baenke, Franziska
Peck, Barrie
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Peck, Barrie
Miess, Heike
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
Miess, Heike
Schulze, Almut
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, EnglandCanc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
de la Cova, Claire
Senoo-Matsuda, Nanami
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Waseda Univ, Sch Adv Sci & Engn, Dept Life Sci & Med BioSci, Shinjuku Ku, Tokyo 1628480, JapanColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Senoo-Matsuda, Nanami
Ziosi, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Univ Bologna, Dept Expt Pathol, I-40126 Bologna, ItalyColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Ziosi, Marcello
Wu, D. Christine
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Wu, D. Christine
Bellosta, Paola
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Bellosta, Paola
Quinzii, Catarina M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
Quinzii, Catarina M.
Johnston, Laura A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USAColumbia Univ, Med Ctr, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
机构:
Univ Modena, Dept Med Sci, I-41100 Modena, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Galletti, Margherita
Riccardo, Sara
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Riccardo, Sara
Parisi, Federica
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USA
Alma Mater Studiorum, Dept Expt Pathol, Bologna, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Parisi, Federica
Lora, Carlina
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Lora, Carlina
Saqcena, Mahesh Kumar
论文数: 0引用数: 0
h-index: 0
机构:
CUNY, Queens Coll, Dept Chem & Biochem, New York, NY USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Saqcena, Mahesh Kumar
Rivas, Leinny
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Rivas, Leinny
Wong, Bonnie
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Wong, Bonnie
Serra, Alexis
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Serra, Alexis
Serras, Florenci
论文数: 0引用数: 0
h-index: 0
机构:
Univ Barcelona, Dept Genet, Barcelona, SpainCUNY City Coll, Dept Biol, New York, NY 10031 USA
Serras, Florenci
Grifoni, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Alma Mater Studiorum, Dept Expt Pathol, Bologna, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Grifoni, Daniela
Pelicci, PierGiuseppe
论文数: 0引用数: 0
h-index: 0
机构:
European Inst Oncol, Milan, ItalyCUNY City Coll, Dept Biol, New York, NY 10031 USA
Pelicci, PierGiuseppe
Jiang, Jin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USACUNY City Coll, Dept Biol, New York, NY 10031 USA
Jiang, Jin
Bellosta, Paola
论文数: 0引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biol, New York, NY 10031 USACUNY City Coll, Dept Biol, New York, NY 10031 USA