Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives

被引：16

作者：

Chen, Xue-Bing ^{[1
]}

Xiong, Sheng-Li ^{[1
]}

Xie, Zhi-Xu ^{[1
]}

Wang, Yong-Chao ^{[2
]}

Liu, Wei ^{[1
]}

机构：

[1] Honghe Univ, Sch Sci, Mengzi 661100, Yunnan, Peoples R China

[2] Yunnan Normal Univ, Sch Vocat & Tech Educ, Kunming 650092, Yunnan, Peoples R China

来源：

ACS OMEGA | 2019年 / 4卷 / 07期

关键词：

MULTIPLE C-C; FACILE SYNTHESIS; EFFICIENT CONSTRUCTION; SELECTIVE INHIBITORS; CONVERGENT SYNTHESIS; DOMINO REACTIONS; CASCADE REACTION; MULTICOMPONENT; ALKALOIDS; ENAMINONES;

D O I：

10.1021/acsomega.9b01159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we detail the development of a concise and efficient three-component protocol for the regioselective synthesis of highly functionalized bis-indoles through a one-pot, two-step sequential process starting from enaminones 1, indoles 2, and acenaphthylene-1,2-dione 3 that is catalyzed by piperidine and p-methyl benzenesulfonic acid. This protocol has several advantages including simplicity of experimental operation, high efficiency of bond formation, ready availability and low cost of starting materials, environmentally benign conditions, and target molecular diversity.

引用

页码：11832 / 11837

页数：6

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