Redefining the Phenotype of Dental Caries

被引：30

作者：

Weber, Megan ^{[1
]}

Sovik, Jenny Bogstad ^{[2
]}

Mulic, Aida ^{[2
,3
]}

Deeley, Kathleen ^{[1
]}

Tveit, Anne B. ^{[2
]}

Forella, Jessalyn ^{[1
]}

Shirey, Nicholas ^{[1
]}

Vieira, Alexandre R. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Dent Med, 335 Sutherland Dr, Pittsburgh, PA 15261 USA

[2] Univ Oslo, Dept Cariol, Oslo, Norway

[3] Nord Inst Dent Mat NIOM, Oslo, Norway

来源：

CARIES RESEARCH | 2018年 / 52卷 / 04期

关键词：

Caries prediction; Genetics; Saliva; Caries detection; ENAMEL FORMATION; GENETIC-VARIATION; CHILDHOOD CARIES; EXPERIENCE; ASSOCIATION; CHILDREN; POPULATION; FLUORIDE; LINKAGE; GLANDS;

D O I：

10.1159/000481414

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Dental caries is a multifactorial infectious disease and a major public health problem estimated to affect 60-90% of school children as well as a vast number of adults. The aim of this work was to define patterns of progression of the disease based on longitudinal data in contrast to using a cross-sectional assessment. dmft/DMFT scores were collected at ages 5, 12, 14, 16, 17, and 18 from 876 individuals. We tested our newly defined phenotypes for association with genetic variants in genes shown to be associated with caries. We generated genotyping data using Taqman chemistry in markers of genes involved in processes such as enamel formation and salivary contributions. Kallikrein 4 (KLK4) was found to show a significant association with the created phenotypes (p = 0.0008 in a recessive model for low caries experience in the primary dentition vs. high caries experience in the primary dentition, and p = 0.0004 in a recessive model for caries free primary dentition vs. high caries experience in the primary dentition). (C) 2018 S. Karger AG, Basel

引用

页码：263 / 271

页数：9

共 34 条

[1] Early Childhood Caries Is Associated with Genetic Variants in Enamel Formation and Immune Response Genes [J].

Abbasoglu, Zerrin ;

Tanboga, Ilknur ;

Kuechler, Erika Calvano ;

Deeley, Kathleen ;

Weber, Megan ;

Kaspar, Cigdem ;

Korachi, May ;

Vieira, Alexandre R. .

CARIES RESEARCH, 2015, 49 (01) :70-77

[2] Aquaporin 5 Interacts with Fluoride and Possibly Protects against Caries [J].

Anjomshoaa, Ida ;

Briseno-Ruiz, Jessica ;

Deeley, Kathleen ;

Poletta, Fernardo A. ;

Mereb, Juan C. ;

Leite, Aline L. ;

Barreta, Priscila A. T. M. ;

Silva, Thelma L. ;

Dizak, Piper ;

Ruff, Timothy ;

Patir, Asli ;

Koruyucu, Mine ;

Abbasoglu, Zerrin ;

Casado, Priscila L. ;

Brown, Andrew ;

Zaky, Samer H. ;

Bayram, Merve ;

Kuechler, Erika C. ;

Cooper, Margaret E. ;

Liu, Kai ;

Marazita, Mary L. ;

Tanboga, Ilknur ;

Granjeiro, Jose M. ;

Seymen, Figen ;

Castilla, Eduardo E. ;

Orioli, Ieda M. ;

Sfeir, Charles ;

Owyang, Hongjiao ;

Buzalaf, Marilia A. R. ;

Vieira, Alexandre R. .

PLOS ONE, 2015, 10 (12)

[3] Role of TRAV locus in low caries experience [J].

Briseno-Ruiz, Jessica ;

Shimizu, Takehiko ;

Deeley, Kathleen ;

Dizak, Piper M. ;

Ruff, Timothy D. ;

Faraco, Italo M., Jr. ;

Poletta, Fernando A. ;

Brancher, Joao A. ;

Pecharki, Giovana D. ;

Kuechler, Erika C. ;

Tannure, Patricia N. ;

Lips, Andrea ;

Vieira, Thays C. S. ;

Patir, Asli ;

Koruyucu, Mine ;

Mereb, Juan C. ;

Resick, Judith M. ;

Brandon, Carla A. ;

Letra, Ariadne ;

Silva, Renato M. ;

Cooper, Margaret E. ;

Seymen, Figen ;

Costa, Marcelo C. ;

Granjeiro, Jose M. ;

Trevilatto, Paula C. ;

Orioli, Ieda M. ;

Castilla, Eduardo E. ;

Marazita, Mary L. ;

Vieira, Alexandre R. .

HUMAN GENETICS, 2013, 132 (09) :1015-1025

[4] A mouse caries model and evaluation of AQP5-/- knockout mice [J].

Culp, DJ ;

Quivey, RG ;

Bowen, WH ;

Fallon, MA ;

Pearson, SK ;

Faustoferri, R .

CARIES RESEARCH, 2005, 39 (06) :448-454

[5] Possible association of amelogenin to high caries experience in a guatemalan-mayan population [J].

Deeley, K. ;

Letra, A. ;

Rose, E. K. ;

Brandon, C. A. ;

Resick, J. M. ;

Marazita, M. L. ;

Vieira, A. R. .

CARIES RESEARCH, 2008, 42 (01) :8-13

[6] Genetic variation in Ameloblastin is associated with caries in asthmatic children [J].

Ergöz N. ;

Seymen F. ;

Gencay K. ;

Tamay Z. ;

Deeley K. ;

Vinski S. ;

Vieira A.R. .

European Archives of Paediatric Dentistry, 2014, 15 (3) :211-216

[7]

Fejerskov O., 2008, DENT CARIES DIS ITS

[8] Global Burden of Untreated Caries: A Systematic Review and Metaregression [J].

Kassebaum, N. J. ;

Bernabe, E. ;

Dahiya, M. ;

Bhandari, B. ;

Murray, C. J. L. ;

Marcenes, W. .

JOURNAL OF DENTAL RESEARCH, 2015, 94 (05) :650-658

[9] Genetic variation in the promoter region of beta-defensin 1 (DEFB 1) is associated with high caries experience in children born with cleft lip and palate [J].

Krasone, Kristine ;

Lace, Baiba ;

Akota, Ilze ;

Care, Ruta ;

Deeley, Kathleen ;

Kuechler, Erika C. ;

Vieira, Alexandre R. .

ACTA ODONTOLOGICA SCANDINAVICA, 2014, 72 (03) :235-240

[10] Fine mapping of locus Xq25.1-27-2 for a low caries experience phenotype [J].

Kuechler, Erika C. ;

Feng, Ping ;

Deeley, Kathleen ;

Fitzgerald, Carly A. ;

Meyer, Chelsea ;

Gorbunov, Anastasia ;

Bezamat, Mariana ;

Reis, Maria Fernanda ;

Noel, Jacqueline ;

Kouzbari, M. Zahir ;

Granjeiro, Jose M. ;

Antunes, Leonardo S. ;

Antunes, Livia A. ;

de Abreu, Fernanda Volpe ;

Costa, Marcelo C. ;

Tannure, Patricia N. ;

Seymen, Figen ;

Koruyucu, Mine ;

Patir, Asli ;

Vieira, Alexandre R. .

ARCHIVES OF ORAL BIOLOGY, 2014, 59 (05) :479-486

← 1 2 3 4 →