The evolution of anticoagulant therapy

被引：71

作者：

Franchini, Massimo ^{[1
]}

Liumbruno, Giancarlo M. ^{[2
]}

Bonfanti, Carlo ^{[1
]}

Lippi, Giuseppe ^{[3
]}

机构：

[1] Carlo Poma Hosp, Dept Haematol & Transfus Med, Mantua, Italy

[2] Natl Inst Hlth, Italian Natl Blood Ctr, Rome, Italy

[3] Univ Verona, Sect Clin Biochem, I-37100 Verona, Italy

来源：

BLOOD TRANSFUSION | 2016年 / 14卷 / 02期

关键词：

unfractionated heparin; low molecular weight heparin; vitamin K antagonists; warfarin; new oral anticoagulants; ORAL FACTOR XA; SYMPTOMATIC VENOUS THROMBOEMBOLISM; MOLECULAR-WEIGHT HEPARINS; TOTAL KNEE ARTHROPLASTY; TOTAL HIP-ARTHROPLASTY; VITAMIN-K ANTAGONISTS; ED AMERICAN-COLLEGE; ATRIAL-FIBRILLATION; ANTITHROMBOTIC THERAPY; DABIGATRAN ETEXILATE;

D O I：

10.2450/2015.0096-15

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Arterial and venous thromboembolism are leading causes of morbidity and mortality around the world. For almost 70 years, heparins (unfractionated heparin and low molecular weight heparins) and vitamin K antagonists have been the leading therapeutic medical options for the treatment and prevention of thromboembolic disorders. Nevertheless, the many limitations of these traditional anticoagulants have fuelled the search for novel agents over the past 15 years, and a new class of oral anticoagulants that specifically target activated factor X and thrombin has been developed and is now commercially available. In this narrative review, the evolution of anticoagulant therapy is summarised, with a focus on newer oral anticoagulants.

引用

页码：175 / 184

页数：10

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