Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis

被引：150
作者：
Noguchi, C [1 ]
Niki, E [1 ]
机构：
[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2000年 / 28卷 / 10期
关键词：
free radical; antioxidant; LDL oxidation; lipid peroxidation; alpha-tocopherol; probucol;
D O I：
10.1016/S0891-5849(00)00256-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With increasing evidence that shows the involvement of active oxygen and nitrogen species in a variety of disorders, cancer, and aging, the role of antioxidant against oxidative stress has received renewed attention. In this review article, a rationale for design of lipophilic, radical-scavenging antioxidant is presented and the potency of a novel antioxidant, 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BO-653), as an inhibitor of LDL oxidation was evaluated by considering various factors such as reactivity toward radicals, localization, and mobility in the lipoprotein, and fate of its radical. The anti-atherogenic activity of BO-653 was compared with those of alpha-tocopherol, probucol, and its metabolites. Furthermore, a novel function of phenolic antioxidants such as cell regulation and induction of phase II defense antioxidants are also discussed. (C) 2000 Elsevier Science Inc.
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收藏
页码：1538 / 1546
页数：9
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