Ironing out VPS34 inhibition

被引:21
|
作者
Marsh, Timothy [1 ]
Debnath, Jayanta
机构
[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
关键词
AUTOPHAGY; MECHANISMS; 3-KINASE; CELLS; HOMEOSTASIS; RECEPTOR; NCOA4;
D O I
10.1038/ncb3089
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes. © 2015 Macmillan Publishers Limited. All rights reserved.
引用
收藏
页码:1 / 3
页数:3
相关论文
共 50 条
  • [1] In Vitro Characterization of VPS34 Lipid Kinase Inhibition by Small Molecules
    Fassy, F.
    Dureuil, C.
    Lamberton, A.
    Mathieu, M.
    Michot, N.
    Ronan, B.
    Pasquier, B.
    MOLECULAR CHARACTERIZATION OF AUTOPHAGIC RESPONSES, PT A, 2017, 587 : 447 - 464
  • [2] Activation Mechanisms of the VPS34 Complexes
    Ohashi, Yohei
    CELLS, 2021, 10 (11)
  • [3] VPS34 Complexes in Plants: Untangled Enough?
    Bhati, Kaushal Kumar
    Luong, Ai My
    Batoko, Henri
    TRENDS IN PLANT SCIENCE, 2021, 26 (04) : 303 - 305
  • [4] Targeting VPS34 in autophagy: An update on pharmacological small-molecule compounds
    Liu, Yuan
    Yang, Qilin
    Chen, Siwei
    Li, Zixiang
    Fu, Leilei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 256
  • [5] Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34
    Robke, Lucas
    Laraia, Luca
    Corrales, Marjorie A. Carnero
    Konstantinidis, Georgios
    Muroi, Makoto
    Richters, Andre
    Winzker, Michael
    Engbring, Tobias
    Tomassi, Stefano
    Watanabe, Nobumoto
    Osada, Hiroyuki
    Rauh, Daniel
    Waldmann, Herbert
    Wu, Yao-Wen
    Engel, Julian
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (28) : 8153 - 8157
  • [6] Aurone derivatives as Vps34 inhibitors that modulate autophagy
    Guodong Li
    Joshua William Boyle
    Chung-Nga Ko
    Wu Zeng
    Vincent Kam Wai Wong
    Jian-Bo Wan
    Philip Wai Hong Chan
    Dik-Lung Ma
    Chung-Hang Leung
    Acta Pharmaceutica Sinica B, 2019, 9 (03) : 537 - 544
  • [7] Aurone derivatives as Vps34 inhibitors that modulate autophagy
    Li, Guodong
    Boyle, Joshua William
    Ko, Chung-Nga
    Zeng, Wu
    Wong, Vincent Kam Wai
    Wan, Jian-Bo
    Chan, Philip Wai Hong
    Ma, Dik-Lung
    Leung, Chung-Hang
    ACTA PHARMACEUTICA SINICA B, 2019, 9 (03) : 537 - 544
  • [8] Unveiling the Secrets of the Ancestral PI3 Kinase Vps34
    Workman, Paul
    van Montfort, Rob L. M.
    CANCER CELL, 2010, 17 (05) : 421 - 423
  • [9] Ubiquitination status does not affect Vps34 degradation
    Tang, Jing
    Sun, Fei
    Deng, Xiao-Juan
    Ma, Yuan-Lin
    Li, Kun-Yi
    Tang, Ying
    Chen, Guo-Jun
    GENES & DISEASES, 2020, 7 (03) : 401 - 407
  • [10] Firing up the cold tumors by targeting Vps34
    Janji, Bassam
    Hasmim, Meriem
    Parpal, Santiago
    Berchem, Guy
    Noman, Muhammad Zaeem
    ONCOIMMUNOLOGY, 2020, 9 (01):