New norditerpenoids with trypanocidal activity from Vitex trifolia

被引：47

作者：

Kiuchi, F

Matsuo, K

Ito, M

Qui, TK

Honda, G

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Natl Inst Hlth Sci, Tsukuba Med Plant Res Stn, Tsukuba, Ibaraki 3050843, Japan

[3] Vietnam Natl Univ, Res Ctr Appl Chem, Ho Chi Minh City, Vietnam

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 12期

关键词：

Vitex trifolia; Verbenaceae; norditerpene aldehyde; trypanocidal cruzi;

D O I：

10.1248/cpb.52.1492

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11mum (1), 36mum (2),34mum (3),34mum (4), 66mum (5), 66mum (6), and >265mum (7).

引用

页码：1492 / 1494

页数：3

共 8 条

[1]

Bastien Joseph, 1998, The Kiss of Death: Chagas Disease in the Americas

[2]

KIMURA T, 1996, INT COLLATION TRADIT, V1, P66

[3] Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides [J].