Circadian misalignment increases cardiovascular disease risk factors in humans

被引:467
作者
Morris, Christopher J. [1 ,2 ,3 ]
Purvis, Taylor E. [1 ,2 ]
Hu, Kun [1 ,2 ,3 ]
Scheer, Frank A. J. L. [1 ,2 ,3 ]
机构
[1] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Med Chronobiol Program, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Med, Div Sleep Med, Boston, MA 02115 USA
基金
美国国家航空航天局;
关键词
circadian misalignment; hypertension; inflammatory markers; night work; shift work; AMBULATORY BLOOD-PRESSURE; C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA; SHIFT WORK; SLEEP RESTRICTION; INFLAMMATORY MARKERS; INSUFFICIENT SLEEP; RATE-VARIABILITY;
D O I
10.1073/pnas.1516953113
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in humans. Here we show-by using two 8d laboratory protocols-that short-term circadian misalignment (12-h inverted behavioral and environmental cycles for three days) adversely affects cardiovascular risk factors in healthy adults. Circadian misalignment increased 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 3.0 mmHg and 1.5 mmHg, respectively. These results were primarily explained by an increase in blood pressure during sleep opportunities (SBP, +5.6 mmHg; DBP, +1.9 mmHg) and, to a lesser extent, by raised blood pressure during wake periods (SBP, +1.6 mmHg; DBP, +1.4 mmHg). Circadian misalignment decreased wake cardiac vagal modulation by 8-15%, as determined by heart rate variability analysis, and decreased 24-h urinary epinephrine excretion rate by 7%, without a significant effect on 24-h urinary norepinephrine excretion rate. Circadian misalignment increased 24-h serum interleukin-6, C-reactive protein, resistin, and tumor necrosis factor-a levels by 3-29%. We demonstrate that circadian misalignment per se increases blood pressure and inflammatory markers. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.
引用
收藏
页码:E1402 / E1411
页数:10
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