Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses

被引:5
作者
Villalobos-Garcia, Daniel [1 ]
Ali, Hamdy E. A. [1 ]
Alarabi, Ahmed B. [2 ]
El-Halawany, Medhat S. [1 ]
Alshbool, Fatima Z. [2 ]
Khasawneh, Fadi T. [1 ]
机构
[1] Texas A&M Univ, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, Kingsville, TX 78363 USA
[2] Texas A&M Univ, Irma Lerma Rangel Coll Pharm, Dept Pharm Practice, Kingsville, TX 78363 USA
基金
美国国家卫生研究院;
关键词
thirdhand smoke; platelet; thrombosis; hemostasis; tobacco; CIGARETTE-SMOKING; ELIMINATION KINETICS; LUNG CARCINOGEN; 2ND-HAND SMOKE; TOBACCO; NICOTINE; QUANTITATION; METABOLITES; SECONDHAND; IMPACT;
D O I
10.3390/ijms23105595
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Smoking is a risk factor for a variety of deleterious conditions, such as cancer, respiratory disease and cardiovascular disease. Thrombosis is an important and common aspect of several cardiovascular disease states, whose risk is known to be increased by both first- and secondhand smoke. More recently, the residual cigarette smoke that persists after someone has smoked (referred to as thirdhand smoke or THS) has been gaining more attention, since it has been shown that it also negatively affects health. Indeed, we have previously shown that 6-month exposure to THS increases the risk of thrombogenesis. However, neither the time-dependence of THS-induced thrombus formation, nor its sex dependence have been investigated. Thus, in the present study, we investigated these issues in the context of a shorter exposure to THS, specifically 3 months, in male and female mice. We show that the platelets from 3-month THS-exposed mice exhibited enhanced activation by agonists. Moreover, we also show that mice of both sexes exposed to THS have decreased tail bleeding as well as decreased thrombus occlusion time. In terms of the role of sex, intersex disparities in thrombus development and hemostasis as well as in platelet aggregation were, interestingly, observed. Together, our findings show that exposing mice to THS for 3 months is sufficient to predispose them to thrombosis; which seems to be driven, at least in part, by an increased activity in platelets, and that it does not manifest equally in both sexes.
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页数:12
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