Overview of the development and current use of CRM197 conjugate vaccines for pediatric use

被引：92
作者：
Shinefield, Henry R.
机构：
[1] New York, NY 10021, 370 First Street
来源：
VACCINE | 2010年 / 28卷 / 27期
关键词：
Conjugate vaccines; CRM197; Pediatric vaccines; INVASIVE PNEUMOCOCCAL DISEASE; MENINGOCOCCAL GLYCOCONJUGATE VACCINE; IMMUNE-RESPONSE; IMMUNOGENICITY; IMMUNIZATION; CARRIAGE; CHILDREN; SAFETY; EPIDEMIOLOGY; SURVEILLANCE;
D O I：
10.1016/j.vaccine.2010.04.072
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Glycoconjugate vaccines have been proven safe and effective against various diseases in children. Although these vaccines have a history of effectiveness, there are still many unanswered questions to be addressed, including conjugate interference when multiple vaccines are administered at one time, expansion of serotype coverage, effectiveness in special populations, and issues relating to conjugate vaccine use in the developing world. This paper focuses on the use of CRM197 as a carrier protein, contrasting it to other carrier proteins used in single-antigen pediatric vaccines as well as identifying areas for future study. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4335 / 4339
页数：5
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