Circadian rhythms, adrenergic hormones and trafficking of hematopoietic stem cells

被引：13

作者：

Giudice, Aldo ^{[2
]}

Caraglia, Michele ^{[1
]}

Marra, Monica ^{[1
]}

Montella, Maurizio ^{[3
]}

Maurea, Nicola ^{[4
]}

Abbruzzese, Alberto ^{[1
]}

Arra, Claudio ^{[2
]}

机构：

[1] Univ Naples 2, Dept Biochem & Biophys, I-80138 Naples, Italy

[2] Natl Canc Inst Fdn G Pascale, Anim Facil Unit, I-80131 Naples, Italy

[3] G Pascale Fdn, Natl Canc Inst, Div Cardiol, I-80131 Naples, Italy

[4] G Pascale Fdn, Natl Canc Inst, Dept Epidemiol, I-80131 Naples, Italy

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2010年 / 14卷 / 05期

关键词：

circadian ryhtms; CXCL12; CXCR4; hematopoiesis; beta(3)-adrenergic receptor; SYMPATHETIC-NERVOUS-SYSTEM; BONE-MARROW; PROGENITOR CELLS; IMMUNE-SYSTEM; NICHES; DIFFERENTIATION; PROLIFERATION; MOBILIZATION; MODULATION; EXPRESSION;

D O I：

10.1517/14728221003769887

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered in this review: It has been shown that circulating HSCs exhibit marked circadian fluctuations due to standard cycles of 12 h light/12 h darkness. Circadian HSCs oscillations are strongly altered when mice are subjected to continuous light for two weeks or to a jet lag. In addition, circulating HSCs fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment. Circadian HSC trafficking and expression of CXCL12 are modulated by core genes of the central clock through rhythmic secretion of adrenergic hormones from nerve terminals of the sympathetic nervous system (SNS) in the bone marrow. What the reader will gain: This review summarizes recent findings on the circadian regulation of HSC release in the bone marrow examining the molecular mechanisms through which the central molecular clock regulates CXCL12 in bone marrow stromal cells through rhythmic secretion of adrenergic hormones locally delivered in the bone marrow by nerve terminals from the SNS. Take home message: The circadian HSCs trafficking during steady-state conditions, may promote the maintenance of haematopoiesis through the life of individuals.

引用

页码：567 / 575

页数：9

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