Recent developments in biological activities of chalcones: A mini review

被引：593
作者：
Singh, Parvesh [1 ]
Anand, Amit [2 ]
Kumar, Vipan [3 ]
机构：
[1] Univ KwaZulu Natal, Sch Chem & Phys, ZA-4000 Durban, South Africa
[2] Khalsa Coll, Dept Chem, Amritsar 143005, Punjab, India
[3] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 85卷
关键词：
Chalcones; Anticancer agents; Antimalarials; Antimicrobials; Antiprotozal; Anti-HIV; ANTICANCER ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; PLASMODIUM-FALCIPARUM; ANTIMALARIAL ACTIVITY; ALDOL CONDENSATIONS; CYTOTOXIC ACTIVITY; AGENTS SYNTHESIS; TNF-ALPHA; DERIVATIVES;
D O I：
10.1016/j.ejmech.2014.08.033
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chalcones represent key structural motif in the plethora of biologically active molecules including synthetic and natural products. Synthetic manipulations of chalcones or their isolation from natural sources are being investigated worldwide for the development of more potent and efficient drugs for the treatment of several dreadful diseases such as cancer, diabetes, HIV, tuberculosis, malaria etc. Over the past few years, a large volume of research papers and review articles highlighting the significance of chalcone derivatives has been compiled in the literature. The present review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：758 / 777
页数：20
相关论文
共 129 条
[1]   Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity [J].
Abonia, Rodrigo ;
Insuasty, Daniel ;
Castillo, Juan ;
Insuasty, Braulio ;
Quiroga, Jairo ;
Nogueras, Manuel ;
Cobo, Justo .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 57 :29-40
[2]  
Ajaiyeoba E O, 2013, J Parasitol Res, V2013, P703781, DOI 10.1155/2013/703781
[3]   SYNTHESIS OF 2'-HYDROXYCHALCONES AND RELATED-COMPOUNDS IN INTERFACIAL SOLID-LIQUID CONDITIONS [J].
ALCANTARA, AR ;
MARINAS, JM ;
SINISTERRA, JV .
TETRAHEDRON LETTERS, 1987, 28 (14) :1515-1518
[4]   Antiobesity, antioxidant and cytotoxicity activities of newly synthesized chalcone derivatives and their metal complexes [J].
Aly, Mohamed Ramadan El Sayed ;
Fodah, Hamadah Hamadah Abd El Razek ;
Saleh, Sherif Yousef .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 76 :517-530
[5]   Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis [J].
Anthwal, Amit ;
Rajesh, U. Chinna ;
Rawat, M. S. M. ;
Kushwaha, Bhavana ;
Maikhuri, Jagdamba P. ;
Sharma, Vishnu L. ;
Gupta, Gopal ;
Rawat, Diwan S. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 79 :89-94
[6]   Synthesis and antimicrobial studies of chalconyl pregnenolones [J].
Banday, Abid H. ;
Zargar, M. Iqbal ;
Ganaie, Bashir A. .
STEROIDS, 2011, 76 (12) :1358-1362
[7]   Synthesis and biological evaluation of β-chloro vinyl chalcones as inhibitors of TNF-α and IL-6 with antimicrobial activity [J].
Bandgar, Babasaheb P. ;
Patil, Sachin A. ;
Korbad, Balaji L. ;
Nile, Shivraj H. ;
Khobragade, Chandrahase N. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (06) :2629-2633
[8]   Synthesis and biological screening of a combinatorial library of β-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents [J].
Bandgar, Babasaheb P. ;
Gawande, Shrikant S. .
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (05) :2060-2065
[9]   Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents [J].
Bandgar, Babasaheb P. ;
Gawande, Shrikant S. ;
Bodade, Ragini G. ;
Totre, Jalinder V. ;
Khobragade, Chandrahas N. .
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (03) :1364-1370
[10]   Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents [J].
Bandgar, Babasaheb P. ;
Patil, Sachin A. ;
Gacche, Rajesh N. ;
Korbad, Balaji L. ;
Hote, Balwant S. ;
Kinkar, Santosh N. ;
Jalde, Shivkumar S. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (02) :730-733
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