Sensitive detection of clozapine using a gold electrode modified with 16-mercaptohexadecanoic acid self-assembled monolayer

被引：30

作者：

Huang, Fei ^{[1
]}

Qu, Song ^{[1
]}

Zhang, Song ^{[1
]}

Liu, Baohong ^{[1
]}

Kong, Jilie ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

TALANTA | 2007年 / 72卷 / 02期

基金：

中国国家自然科学基金;

关键词：

clozapine; 16-mercaptohexadecanoic acid; self-assembled monolayer; detection; gold electrode; characterization;

D O I：

10.1016/j.talanta.2006.11.004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Clozapine, an effective antipsychotic drug, was found generating a pair of redox peaks at about 0.33-0.4V (versus SCE) at 16-mercaptohexadecanoic acid (i.e. MHA) self-assembled monolayer (SAM) modified gold electrode (i.e. MHA/Au) in 0.05 mol L-1 Tris-HCl (pH 8.1) buffer solution. Sensitive and quantitative measurement of clozapine based on anodic peak was established under optimum conditions. The anodic peak current was linear to clozapine concentration in the range from 1 X 10(-6) to 5 x 10(-5) mol L-1 with the detection limit of 7 x 10(-9) mol L-1. This method was successfully applied to the detection of clozapine in drug tablets and proved to be reliable compared with ultraviolet spectrophotometry (UV). The MHA SAM was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), contact angle goniometry, electrochemical impedance spectroscopy (EIS) and electrochemical probe. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：457 / 462

页数：6

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