Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

被引:82
作者
Araújo, MJ
Bom, J
Capela, R
Casimiro, C
Chambel, P
Gomes, P
Iley, J
Lopes, F
Morais, J
Moreira, R
de Oliveira, E
do Rosário, V
Vale, N
机构
[1] Univ Lisbon, Fac Pharm, CECF, P-1649019 Lisbon, Portugal
[2] Univ Lisbon, Fac Pharm, UCTM, P-1649019 Lisbon, Portugal
[3] Univ Porto, Fac Sci, Dept Chem, CIQUP, P-4169007 Oporto, Portugal
[4] Open Univ, Dept Chem, Milton Keynes MK7 6AA, Bucks, England
[5] Ist Higiene & Med Trop, CMDT, P-1000 Lisbon, Portugal
[6] Proteom Platform, E-08028 Barcelona, Spain
关键词
D O I
10.1021/jm0494624
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Imidazolidin-4-one derivatives of primaquine were synthesized as potential double prodrugs of the parent drug. The title compounds inhibit the development of the sporogonic cycle of Plasmodium berghei, affecting the appearance of oocysts in the midguts of the mosquitoes. The imidazolidin-4-ones are very stable, both in human plasma and in pH 7.4 buffer, indicating that they are active per se. Thus, imidazolidin-4-ones derived from 8-aminoquinolines represent a new entry in antimalarial structure-activity relationships.
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页码:888 / 892
页数:5
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