Synthesis of [14C]-L-tryptophan and [14C]-5′-hydroxy-L-tryptophan labeled in the carboxyl group

被引：4

作者：

Boroda, E ^{[1
]}

Kanski, R ^{[1
]}

Kanska, M ^{[1
]}

机构：

[1] Univ Warsaw, Dept Chem, PL-02089 Warsaw, Poland

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 05期

关键词：

C-14-labeling; optical isotopomer; L-tryptophan; 5 '-hydroxy-L-tryptophan; enzyme;

D O I：

10.1002/jlcr.685

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of selectively C-14-labeled L-tryptophan and its derivative 5-hydroxy-L-tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1-C-14[-DL-alanine, indole or 5-hydroxyindole has been converted to [1-C-14]-L-tryptophan or 5'-hydroxy-[1-C-14]-L-tryptophan, respectively, in a one-pot multienzymatic reaction using four enzymes: D-amino acid oxidase, catalase, glutamic-pyruvic transaminase and tryptophanase. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：441 / 447

页数：7

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