Conductive sol-gel hybrid materials for novel cofactor regeneration in biocatalysis

被引:1
|
作者
Won, Keehoon
Siu, Eulaia [2 ]
Park, Chan Beum [1 ,2 ,3 ]
机构
[1] Korea Res Inst Chem Technol, 100 Jang Dong, Taejon 305343, South Korea
[2] Arizona State Univ, Dept Chem & Mat Sci, Tempe, AZ 85287 USA
[3] Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Taejon 305701, South Korea
来源
ADVANCES IN NANOMATERIALS AND PROCESSING, PTS 1 AND 2 | 2007年 / 124-126卷
关键词
conductive hybrid gel; electrochemical cofactor regeneration; biocatalysis;
D O I
10.4028/www.scientific.net/SSP.124-126.1087
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The electrochemical recycling of cofactors during enzymatic biocatalysis has long been acknowledged as a potentially powerful technology in fine chemical synthesis. Major obstacle for this approach is that cofactors only in the immediate vicinity of the electrode surface are productive. This problem further causes high overpotential at electrode surfaces leading to undesired side reactions producing enzymatically-inactive dimer and isomer of cofactor. So far, several attempts had been made to address these problems by focusing on surface modifications, which explored to retain the enzyme and/or cofactor close to the working electrode including electrode deposition and membranes surrounding the electrode. In this work, we demonstrate a new concept of cofactor regeneration by using 'electronically-conductive' sol-gel hybrid materials. When conductive hybrid gets were added to the reaction medium, we found that cofactor could be efficiently recycled throughout the whole reactor system leading to high yield of product, which was unattainable with conventional technologies.
引用
收藏
页码:1087 / +
页数:2
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