The emergence of point-of-care blood-based biomarker testing for psychiatric disorders: enabling personalized medicine

被引：21
作者：
Guest, Francesca L. [1 ,2 ]
Guest, Paul C. [3 ]
Martins-de-Souza, Daniel [3 ,4 ]
机构：
[1] Victoria Ctr Mental Hlth Partnership NHS Trust, Swindon SN3 6BW, Avon, England
[2] Victoria Ctr Mental Hlth Partnership NHS Trust, Swindon SN3 6BW, Wilts, England
[3] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Biochem & Tissue Biol,Lab Neuroprote, Rua Monteiro Lobato 255 F-01, BR-13083862 Campinas, SP, Brazil
[4] Univ Estadual Campinas, Neurobiol Ctr, Rua Monteiro Lobato 255,Cidade Univ Zeferino Vaz, BR-13083862 Campinas, SP, Brazil
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 04期
关键词：
lab-on-a-chip; mass spectrometry; mobile apps; multiplex immunoassay; plasmonic biosensing; point of care; proteomics; MULTIPLEX IMMUNOASSAY ANALYSIS; POSTMORTEM PITUITARY-GLANDS; DRUG-NAIVE PATIENTS; DOUBLE-BLIND; SCHIZOPHRENIA-PATIENTS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; BIPOLAR DISORDER; CLINICAL-TRIAL; GROWTH-FACTOR;
D O I：
10.2217/bmm-2015-0055
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
For psychiatric disorders, repeated failures in converting scientific discoveries into novel drugs has precipitated a crisis and eroded confidence in drug discovery. This review describes how current and future innovations driven by application of biomarkers can help to re-initiate research in this area. This will have positive impact on the field of psychiatry and result in application of sensitive and specific biochemical tests in parallel with the traditional questionnaires for improved diagnosis. Furthermore, application of emerging biosensor tools will facilitate point-of-care testing by fusion of biochemical and clinical data. In this way, patient data will be comprised of past medical histories, biopatterns and prognosis information, resulting in personalized profiles or molecular fingerprints for patients with these conditions.
引用
收藏
页码：431 / 443
页数：13
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