Effect of the Procalcitonin Assay on Antibiotic Use in Critically Ill Children

被引:5
作者
Ross, Rachael K. [1 ]
Keele, Luke [2 ]
Kubis, Sherri [3 ]
Lautz, Andrew J. [4 ]
Dziorny, Adam C. [5 ]
Denson, Adam R. [5 ]
O'Connor, Kathleen A. [5 ]
Chilutti, Marianne R. [6 ]
Weiss, Scott L. [5 ]
Gerber, Jeffrey S. [1 ,7 ]
机构
[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Infect Dis,Dept Pediat, Philadelphia, PA 19104 USA
[2] Georgetown Univ, McCourt Sch Publ Policy, Washington, DC USA
[3] Childrens Hosp Philadelphia, Dept Nursing Resp Care & Neurodiagnost Serv, Philadelphia, PA 19104 USA
[4] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Crit Care Med, Cincinnati, OH 45229 USA
[5] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Crit Care Med,Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA
[6] Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA 19104 USA
[7] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Gen Pediat,Dept Pediat, Philadelphia, PA 19104 USA
关键词
antibiotics; critical care; pediatric; procalcitonin; RANDOMIZED CONTROLLED-TRIAL; BIAS REDUCTION; MULTICENTER; SEPSIS; SENSITIVITY; INFECTIONS; THERAPY; IMPACT;
D O I
10.1093/jpids/piy004
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We retrospectively studied the effect of introducing procalcitonin into clinical practice on antibiotic use within a large academic pediatric intensive care unit. In the absence of a standardized algorithm, availability of the procalcitonin assay did not reduce the frequency of antibiotic initiations or the continuation of antibiotics for greater than 72 hours.
引用
收藏
页码:E43 / E46
页数:4
相关论文
共 23 条
  • [1] Albrich WC, 2012, ARCH INTERN MED, V172, P715, DOI 10.1001/archinternmed.2012.770
  • [2] [Anonymous], 2013, Antibiotic resistance threats in the United States
  • [3] Effect of Procalcitonin Testing on Health-care Utilization and Costs in Critically Ill Patients in the United States
    Balk, Robert A.
    Kadri, Sameer S.
    Cao, Zhun
    Robinson, Scott B.
    Lipkin, Craig
    Bozzette, Samuel A.
    [J]. CHEST, 2017, 151 (01) : 23 - 33
  • [4] Existing data analysis in pediatric critical care research
    Bennett, Tellen D.
    Spaeder, Michael C.
    Matos, Renee I.
    Watson, R. Scott
    Typpo, Katri V.
    Khemani, Robinder G.
    Crow, Sheri
    Benneyworth, Brian D.
    Thiagarajan, Ravi R.
    Dean, J. Michael
    Markovitz, Barry P.
    [J]. FRONTIERS IN PEDIATRICS, 2014, 2
  • [5] Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Bouadma, Lila
    Luyt, Charles-Edouard
    Tubach, Florence
    Cracco, Christophe
    Alvarez, Antonio
    Schwebel, Carole
    Schortgen, Frederique
    Lasocki, Sigismond
    Veber, Benoit
    Dehoux, Monique
    Bernard, Maguy
    Pasquet, Blandine
    Regnier, Bernard
    Brun-Buisson, Christian
    Chastre, Jean
    Wolff, Michel
    [J]. LANCET, 2010, 375 (9713) : 463 - 474
  • [6] Impact of Low Procalcitonin Results on Antibiotic Administration in Hospitalized Patients at a Tertiary Care Center
    Brennan M.B.
    Osterby K.
    Schulz L.
    Lepak A.J.
    [J]. Infectious Diseases and Therapy, 2016, 5 (2) : 185 - 191
  • [7] Practice Patterns and Outcomes Associated With Procalcitonin Use in Critically Ill Patients With Sepsis
    Chu, David C.
    Mehta, Anuj B.
    Walkey, Allan J.
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (11) : 1509 - 1515
  • [8] Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial
    de Jong, Evelien
    van Oers, Jos A.
    Beishuizen, Albertus
    Vos, Piet
    Vermeijden, Wytze J.
    Haas, Lenneke E.
    Loef, Bert G.
    Dormans, Tom
    van Melsen, Gertrude C.
    Kluiters, Yvette C.
    Kemperman, Hans
    van den Elsen, Maarten J.
    Schouten, Jeroen A.
    Streefkerk, Joern O.
    Krabbe, Hans G.
    Kieft, Hans
    Kluge, Georg H.
    van Dam, Veerle C.
    van Pelt, Joost
    Bormans, Laura
    Otten, Martine Bokelman
    Reidinga, Auke C.
    Endeman, Henrik
    Twisk, Jos W.
    van de Garde, Ewoudt M. W.
    de Smet, Anne Marie G. A.
    Kesecioglu, Jozef
    Girbes, Armand R.
    Nijsten, Maarten W.
    de lange, Dylan W.
    [J]. LANCET INFECTIOUS DISEASES, 2016, 16 (07) : 819 - 827
  • [9] Fitzmaurice G., 2011, Applied Longitudinal Data Analysis, V2nd
  • [10] Clinical Impact of a Real-Time PCR Assay for Rapid Identification of Staphylococcal Bacteremia
    Frye, Abigail M.
    Baker, Catherine A.
    Rustvold, D. Leif
    Heath, Kim A.
    Hunt, Jessica
    Leggett, James E.
    Oethinger, Margret
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (01) : 127 - 133