Understanding the function of bacterial outer membrane channels by reconstitution into black lipid membranes

被引:68
作者
Van Gelder, P
Dumas, F
Winterhalter, M
机构
[1] Univ Basel, Bioctr, Dept Biophys Chem, CH-4056 Basel, Switzerland
[2] Univ Toulouse 3, Inst Pharmacol & Biol Struct, CNRS, UPR 9062, F-31077 Toulouse, France
关键词
channel; lipid membrane; porin; conductance; noise; gating;
D O I
10.1016/S0301-4622(99)00153-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structural and functional information is obtained by the reconstitution of membrane channel forming proteins into black lipid membranes. Due to this outstanding sensitivity only little material is needed and single molecule detection can be easily achieved. An overview on different types of detection will be given. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:153 / 167
页数:15
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