β-carotene:: Friend or foe?

被引:58
作者
Omaye, ST [1 ]
Krinsky, NI
Kagan, VE
Mayne, ST
Liebler, DC
Bidlack, WR
机构
[1] Univ Nevada, Reno, NV 89557 USA
[2] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA
[3] Tufts Univ, USDA, Jean Mayer Human Nutr Res Ctr Aging, Boston, MA 02111 USA
[4] Univ Pittsburgh, Pittsburgh, PA 15238 USA
[5] Yale Univ, New Haven, CT 06520 USA
[6] Univ Arizona, Tucson, AZ 85721 USA
[7] Calif State Polytech Univ Pomona, Pomona, CA 91768 USA
来源
FUNDAMENTAL AND APPLIED TOXICOLOGY | 1997年 / 40卷 / 02期
关键词
D O I
10.1006/faat.1997.2387
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
This symposium focused on the research which documents benefit and toxicity in beta-carotene supplementation. Reflecting on past and current studies, the panel of experts discussed: (1) the potential harm of a high intake of beta-carotene on selected populations, (2) biochemical antioxidant/prooxidant mechanisms of beta-carotene at the cellular level, (3) potential benefits of other carotenoids and antioxidants, and (4) future directions for research in beta-carotene and other antioxidants. (C) 1997 Society of Toxicology.
引用
收藏
页码:163 / 174
页数:12
相关论文
共 65 条
[1]   alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Effects of base-line characteristics and study compliance [J].
Albanes, D ;
Heinonen, OP ;
Taylor, PR ;
Virtamo, J ;
Edwards, BK ;
Rautalahti, M ;
Hartman, AM ;
Palmgren, J ;
Freedman, LS ;
Haapakoski, J ;
Barrett, MJ ;
Pietinen, P ;
Malila, N ;
Tala, E ;
Liippo, K ;
Salomaa, ER ;
Tangrea, JA ;
Teppo, L ;
Askin, FB ;
Taskinen, E ;
Erozan, Y ;
Greenwald, P ;
Huttunen, JK .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (21) :1560-1570
[2]   EFFECTS OF BETA-CAROTENE SUPPLEMENTATION ON LIPID-PEROXIDATION IN HUMANS [J].
ALLARD, JP ;
ROYALL, D ;
KURIAN, R ;
MUGGLI, R ;
JEEJEEBHOY, KN .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 59 (04) :884-890
[3]  
[Anonymous], 1994, Natural antioxidants in human health and disease
[4]   Carotenoids .2. Genetics and molecular biology of carotenoid pigment biosynthesis [J].
Armstrong, GA ;
Hearst, JE .
FASEB JOURNAL, 1996, 10 (02) :228-237
[5]   FRUIT, VEGETABLES, AND CANCER PREVENTION - A REVIEW OF THE EPIDEMIOLOGIC EVIDENCE [J].
BLOCK, G ;
PATTERSON, B ;
SUBAR, A .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1992, 18 (01) :1-29
[6]   NUTRITION INTERVENTION TRIALS IN LINXIAN, CHINA - SUPPLEMENTATION WITH SPECIFIC VITAMIN MINERAL COMBINATIONS, CANCER INCIDENCE, AND DISEASE-SPECIFIC MORTALITY IN THE GENERAL-POPULATION [J].
BLOT, WJ ;
LI, JY ;
TAYLOR, PR ;
GUO, WD ;
DAWSEY, S ;
WANG, GQ ;
YANG, CS ;
ZHENG, SF ;
GAIL, M ;
LI, GY ;
YU, Y ;
LIU, BQ ;
TANGREA, J ;
SUN, YH ;
LIU, FS ;
FRAUMENI, JF ;
ZHANG, YH ;
LI, B .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (18) :1483-1492
[7]   Carotenoids enhance vitamin E antioxidant efficiency [J].
Bohm, F ;
Edge, R ;
Land, EJ ;
McGarvey, DJ ;
Truscott, TG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (03) :621-622
[8]  
BOWEN HT, 1997, IN PRESS LIPID PEROX
[9]   Structure and properties of carotenoids in relation to function [J].
Britton, G .
FASEB JOURNAL, 1995, 9 (15) :1551-1558
[10]   BETA-CAROTENE - AN UNUSUAL TYPE OF LIPID ANTIOXIDANT [J].
BURTON, GW ;
INGOLD, KU .
SCIENCE, 1984, 224 (4649) :569-573