Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

被引：20

作者：

Stefanou, Maria-Ioanna ^{[1
,2
]}

Baur, David ^{[1
,2
]}

Belardinelli, Paolo ^{[1
,2
]}

Bergmann, Til Ole ^{[1
,2
]}

Blum, Corinna ^{[1
,2
]}

Gordon, Pedro Caldana ^{[1
,2
]}

Nieminen, Jaakko O. ^{[1
,2
,3
]}

Zrenner, Brigitte ^{[1
,2
]}

Ziemann, Ulf ^{[1
,2
]}

Zrenner, Christoph ^{[1
,2
]}

机构：

[1] Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany

[2] Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany

[3] Aalto Univ, Dept Neurosci & Biomed Engn, Espoo, Finland

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2019年 / 150期

基金：

芬兰科学院;

关键词：

Behavior; Issue; 150; real-time; brain state-dependent stimulation; EEG-TMS; corticospinal excitability; motor cortex; human brain plasticity; phase; oscillation; INTERINDIVIDUAL VARIABILITY; CORTICAL EXCITABILITY; EEG; TMS; PLASTICITY;

D O I：

10.3791/59711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of a stimulus to the brain depends not only on the parameters of the stimulus but also on the dynamics of brain activity at the time of the stimulation. The combination of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in a real-time brain state-dependent stimulation system allows the study of relations of dynamics of brain activity, cortical excitability, and plasticity induction. Here, we demonstrate a newly developed method to synchronize the timing of brain stimulation with the phase of ongoing EEG oscillations using a real-time data analysis system. This real-time EEG-triggered TMS of the human motor cortex, when TMS is synchronized with the surface EEG negative peak of the sensorimotor mu-alpha (8-14 Hz) rhythm, has shown differential corticospinal excitability and plasticity effects. The utilization of this method suggests that real-time information about the instantaneous brain state can be used for efficacious plasticity induction. Additionally, this approach enables personalized EEG-synchronized brain stimulation which may lead to the development of more effective therapeutic brain stimulation protocols.

引用

页数：7