Clinical and Prognostic Significance of ANCCA in Squamous Cell Lung Carcinoma Patients

被引：6

作者：

Wang, Dingmiao ^{[1
,2
]}

Pan, Yang ^{[1
]}

Hao, Ting ^{[1
]}

Chen, Yong ^{[1
]}

Qiu, Shiming ^{[1
]}

Chen, Ling ^{[1
]}

Zhao, Jinping ^{[2
]}

机构：

[1] Xianning Cent Hosp, Dept Emergency Med, Xianning City, Hubei Province, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Dept Cardiothorac Surg, Wuhan 430071, Hubei Province, Peoples R China

来源：

ARCHIVES OF MEDICAL RESEARCH | 2016年 / 47卷 / 02期

关键词：

ANCCA; Lung squamous cell carcinoma; Biomarker; Prognosis; HEPATOCELLULAR-CARCINOMA; ONCOGENE ATAD2; PROLIFERATION; CANCER; DIFFERENTIATION; COACTIVATOR; PROGRESSION;

D O I：

10.1016/j.arcmed.2016.04.001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background and Aims. AAA+ nuclear coregulatory cancer associated (ANCCA) has been demonstrated as playing important roles in diverse biological processes including tumorigenesis. However, the clinical and prognostic significance of ANCCA in squamous cell lung carcinoma (SCLC) patients is still unknown. The aim of this study is to identify the role of ANCCA in SCLC patients. Methods. ANCCA mRNA and protein expressions were detected in SCLC tissues and cell lines by real-time PCR and Western blot. We examined the ANCCA protein expression in 152 SCLC samples by immunohistochemistry and analyzed the association between the expression of ANCCA protein and clinicopathological characteristics of SCLC patients. Results. ANCCA mRNA and protein expression are increased in SCLC tissues and cell lines. Moreover, ANCCA protein overexpression was associated with differentiated degree, clinical stage, lymph node metastasis, and distant metastasis. In uni- and multivariate analyses, ANCCA protein overexpression was an independent poor prognostic factor for SCLC patients. Conclusions. ANCCA act as a potential biomarker for therapeutic strategy and prognostic prediction for SCLC. (C) 2016 IMSS. Published by Elsevier Inc.

引用

页码：89 / 95

页数：7

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