Diagnostic challenges for dementia in Australia: are blood-based biomarkers the solution?

被引：2
作者：
Loveland, Paula M. [1 ,2 ,3 ,5 ]
Watson, Rosie [1 ,2 ,3 ]
Yassi, Nawaf [1 ,2 ,3 ,4 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia
[3] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia
[4] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Dept Neurol, Melbourne, Vic, Australia
[5] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, 1G Royal Parade, Melbourne, Vic 3050, Australia
来源：
INTERNAL MEDICINE JOURNAL | 2022年 / 52卷 / 12期
基金：
英国医学研究理事会;
关键词：
dementia; diagnosis; biomarkers; ALZHEIMERS-DISEASE; PERFORMANCE;
D O I：
10.1111/imj.15973
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The burden of dementia will increase as the Australian population ages and grows in coming decades. Early and accurate diagnosis remains challenging, and disproportionately so for particular groups, including rural communities. Recent advances in technology, however, now allow reliable measurement of blood biomarkers that could improve diagnosis in a range of settings. We discuss the most promising biomarker candidates for translation into clinical practice and research in the near future.
引用
收藏
页码：2181 / 2185
页数：5
相关论文
共 26 条
[1]  
[Anonymous], 2012, Dementia in Australia
[2]  
Australian Bureau of Statistics [government website], AG POP
[3]   Red blood cells are the major source of alpha-synuclein in blood [J].
Barbour, Robin ;
Kling, Kristin ;
Anderson, John P. ;
Banducci, Kelly ;
Cole, Tracy ;
Diep, Linnea ;
Fox, Michael ;
Goldstein, Jason M. ;
Soriano, Ferdie ;
Seubert, Peter ;
Chilcote, Tarnie J. .
NEURODEGENERATIVE DISEASES, 2008, 5 (02) :55-59
[4]  
Bradford NK, 2016, RURAL REMOTE HEALTH, V16
[5]   Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis [J].
Bridel, Claire ;
van Wieringen, Wessel N. ;
Zetterberg, Henrik ;
Tijms, Betty M. ;
Teunissen, Charlotte E. ;
Alvarez-Cermeno, Jose C. ;
Andreasson, Ulf ;
Axelsson, Markus ;
Backstrom, David C. ;
Bartos, Ales ;
Bjerke, Maria ;
Blennow, Kaj ;
Boxer, Adam ;
Brundin, Lou ;
Burman, Joachim ;
Christensen, Tove ;
Fialova, Lenka ;
Forsgren, Lars ;
Frederiksen, Jette L. ;
Gisslen, Magnus ;
Gray, Elizabeth ;
Gunnarsson, Martin ;
Hall, Sara ;
Hansson, Oskar ;
Herbert, Megan K. ;
Jakobsson, Joel ;
Jessen-Krut, Jan ;
Janelidze, Shorena ;
Johannsson, Gudmundur ;
Jonsson, Michael ;
Kappos, Ludwig ;
Khademi, Mohsen ;
Khalil, Michael ;
Kuhle, Jens ;
Landen, Mikael ;
Leinonen, Ville ;
Logroscino, Giancarlo ;
Lu, Ching-Hua ;
Lycke, Jan ;
Magdalinou, Nadia K. ;
Malaspina, Andrea ;
Mattsson, Niklas ;
Meeter, Lieke H. ;
Mehta, Sanjay R. ;
Modvig, Signe ;
Olsson, Tomas ;
Paterson, Ross W. ;
Perez-Santiago, Josue ;
Piehl, Fredrik ;
Pijnenburg, Yolande A. L. .
JAMA NEUROLOGY, 2019, 76 (09) :1035-1048
[6]  
Brown L., 2017, Economic cost of dementia in Australia
[7]   Telephone-based screening tools for mild cognitive impairment and dementia in aging studies: a review of validated instruments [J].
Castanho, Teresa C. ;
Amorim, Liliana ;
Zihl, Joseph ;
Palha, Joana A. ;
Sousa, Nuno ;
Santos, Nadine C. .
FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
[8]   Novel fluid biomarkers to differentiate frontotemporal dementia and dementia with Lewy bodies from Alzheimer's disease: A systematic review [J].
Chaudhry, Aiysha ;
Houlden, Henry ;
Rizig, Mie .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 415
[9]   Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis [J].
Chin, Kai Sin ;
Yassi, Nawaf ;
Churilov, Leonid ;
Masters, Colin Louis ;
Watson, Rosie .
PARKINSONISM & RELATED DISORDERS, 2020, 80 :184-193
[10]   A clinicopathological approach to the diagnosis of dementia [J].
Elahi, Fanny M. ;
Miller, Bruce L. .
NATURE REVIEWS NEUROLOGY, 2017, 13 (08) :457-476
123