Drug loading and delivery using nanofibers scaffolds

被引：61

作者：

Mohammadian, Farideh ^{[1
]}

Eatemadi, Ali ^{[2
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[2] Univ Tehran Med Sci, Sch Adv Sci Med, Dept Med Biotechnol, Tehran, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Drug delivery; drug loading; electrospinning; nanofiber; scaffolds; ENDOTHELIAL GROWTH-FACTOR; PLGA ULTRAFINE FIBERS; CONTROLLED-RELEASE; ELECTROSPUN NANOFIBERS; COMPOSITE NANOFIBERS; POLYMER NANOFIBERS; CORNEAL SURFACE; SIRNA DELIVERY; GENE DELIVERY; IN-VITRO;

D O I：

10.1080/21691401.2016.1185726

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent times, notable advancement has been made in the field of electrospinning for the fabrication of numerous types of nanofiber scaffolds. Due to the ultrathin fiber diameter, electrospun nanofiber scaffolds are considered to be an operational delivery system for biomolecules, genes, as well as drugs due to the high specific surface area and stereological porous structure. Here, we introduce some of methods for the integration of drugs and biomolecules within electrospun nanofiber scaffolds, such as blending, surface modification, coaxial process, and emulsion methods. Then, we describe some important biomedical applications of nanofibers in drug delivery systems along with their suitable examples in transdermal systems and wound dressings, cancer therapy, growth factor delivery, nucleic acid delivery, and stem cell delivery.

引用

页码：881 / 888

页数：8

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