A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo

被引：9

作者：

Lund, LH

Wahren, B

Garcia-Blanco, MA

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17182 Solna, Sweden

[4] Karolinska Inst, Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

关键词：

D O I：

10.1099/vir.0.18645-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.

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页码：603 / 606

页数：4

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