Multifunctional Nanostructured Lipid Carriers: Preparation and Characterizations

被引：0
作者：
Xu, Man [1 ]
Li, Guang-Meng [1 ]
Zhang, Hao-Xiang [1 ]
Chen, Xiao-Ming [1 ]
Xie, Mao-Bin [1 ]
机构：
[1] Guangzhou Med Univ, Sch Basic Med Sci, Dept Biomed Engn, Guangzhou 511436, Guangdong, Peoples R China
来源：
TEXTILE BIOENGINEERING AND INFORMATICS SYMPOSIUM (TBIS) PROCEEDINGS, 2019 | 2019年
基金：
中国国家自然科学基金;
关键词：
Glioma; Nanostructured Lipid Carriers; Temozolomide; Indocyanine Green; DRUG-DELIVERY; NANOPARTICLES SLN; NLC; GLIOMAS; SYSTEM; BRAIN;
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
Traditional chemotherapeutic drugs are less effective against glioma, owing to tumour resistance and the blood-brain barrier. In order to maximize their anti-tumour effect, multifunctional nanostructured lipid carriers (NLCs) were prepared and their physico-chemical characterizations are tested in this study. The obtained temozolomide/indocyanine green NLCs (TMZ/ICG-NLCs) possess spherical shapes with a particle size of 155.2 +/- 0.72 nm. The encapsulation efficiency of TMZ and ICG is 41.61% +/- 4.74 and 20.46% +/- 3.54, respectively. TMZ and ICG in NLCs are in an amorphous state and an interaction may occur between the lipids and drugs. TMZ and ICG can be released sequentially within 140 h with a much higher solubility and dissolution rate than the original ones. The excellent physico-chemical properties indicate that TMZ/ICG-NLCs are potential candidates for the treatment of glioma.
引用
收藏
页码：187 / 194
页数：8
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