Photodegradation kinetic study and stability-indicating assay of danazol using high-performance liquid chromatography

被引：0
作者：
Kariem, EAG [1 ]
Abounassif, MA [1 ]
Hagga, ME [1 ]
Al-Khamees, HA [1 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 2-3期
关键词：
danazol; HPLC; UV irradiation; determination; photodegradation; kinetics;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A selective high-performance liquid chromatographic procedure for the stability-indicating determination of danazol in the presence of its photolytic degradation products is demonstrated. The photolysis was carried out in glass vials and quartz cell under UV light at 254 nm. Satisfactory results were obtained for the assay and recovery testing with RSD values less than 2%. Kinetic parameters evaluated comprise the order of reaction and the rate constants of the degradation of the danazol irradiated in glass vials or quartz cell. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：413 / 420
页数：8
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