Crystallization and preliminary X-ray crystallographic studies of mouse autocrine motility factor

被引：2
|
作者：
Naba, N
Tanaka, N [1 ]
Shiraiwa, K
Kusakabe, Y
Funasaka, T
Haga, A
Nagase, H
Raz, A
Nakamura, KT
机构：
[1] Showa Univ, Sch Pharmaceut Sci, Tokyo 1428555, Japan
[2] Wayne State Univ, Sch Med, Dept Pathol, Karmanos Canc Inst, Detroit, MI 48202 USA
[3] Gifu Pharmaceut Univ, Gifu 5028585, Japan
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2004年 / 60卷
关键词：
D O I：
10.1107/S090744490402267X
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Mouse autocrine motility factor (mAMY), a tumour-secreted cytokine that stimulates cell migration in vitro and metastasis in vivo, has been crystallized by the hanging-drop vapour-diffusion method. The crystals belong to the monoclinic space group P2(1), with unit-cell parameters a=69.97, b=115.88, c=73.27 Angstrom, beta=101.76degrees. There are two subunits (one dimer) per asymmetric unit. Complexes with four-, five- and six-carbon carbohydrate phosphate inhibitors have also been crystallized. The crystals diffract to at least 1.8 Angstrom resolution and are suitable for X-ray structure analyses at high resolution.
引用
收藏
页码：2084 / 2086
页数：3
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