Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis

被引：87

作者：

Gomi, Harumi ^{[1
]}

Takada, Tadahiro ^{[2
]}

Hwang, Tsann-Long ^{[3
]}

Akazawa, Kohei ^{[4
]}

Mori, Rintaro ^{[5
]}

Endo, Itaru ^{[6
]}

Miura, Fumihiko ^{[2
]}

Kiriyama, Seiki ^{[7
]}

Matsunaga, Naohisa ^{[8
]}

Itoi, Takao ^{[9
]}

Yokoe, Masamichi ^{[10
]}

Chen, Miin-Fu ^{[3
]}

Jan, Yi-Yin ^{[3
]}

Ker, Chen-Guo ^{[11
]}

Wang, Hsiu-Po ^{[12
]}

Wada, Keita ^{[2
]}

Yamaue, Hiroki ^{[13
]}

Miyazaki, Masaru ^{[14
]}

Yamamoto, Masakazu ^{[15
]}

机构：

[1] Univ Tsukuba, Ctr Global Hlth, Mito Kyodo Gen Hosp, Ibaraki, Japan

[2] Teikyo Univ, Dept Surg, Sch Med, Tokyo, Japan

[3] Lin Kou Chang Gung Mem Hosp, Div Gen Surg, Tayuan, Taiwan

[4] Niigata Univ, Dept Med Informat, Niigata, Japan

[5] Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Tokyo, Japan

[6] Yokohama City Univ, Dept Surg Gastroenterol, Grad Sch Med, Yokohama, Kanagawa, Japan

[7] Ogaki Municipal Hosp, Dept Gastroenterol, Gifu, Japan

[8] Teikyo Univ, Dept Infect Control & Prevent, Tokyo, Japan

[9] Tokyo Med Univ Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan

[10] Japanese Red Cross Nagoya Daini Hosp, Dept Gen Internal Med, Nagoya, Aichi, Japan

[11] Yuans Gen Hosp, Dept Surg, Kaohsiung, Taiwan

[12] Natl Taiwan Univ, Dept Internal Med, Natl Taiwan Univ Hosp, Coll Med, Taipei, Taiwan

[13] Wakayama Med Univ, Sch Med, Dept Surg 2, Wakayama, Japan

[14] Chiba Univ, Grad Sch Med, Chiba, Japan

[15] Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Tokyo, Japan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2017年 / 24卷 / 06期

关键词：

Acute cholangitis; Epidemiology; Microbiology; Mortality; COMPLICATED INTRAABDOMINAL INFECTIONS; TRACT-INFECTIONS; RISK;

D O I：

10.1002/jhbp.452

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundThe international practice guidelines for patients with acute cholangitis and cholecystitis were released in 2007 (TG07) and revised in 2013 (TG13). This study investigated updated epidemiology and outcomes among patients with acute cholangitis on a larger scale for the first time. MethodsThis is an international multi-center retrospective observational study in Japan and Taiwan. All consecutive patients older than 18years of age and given a clinical diagnosis of acute cholangitis by clinicians between 1 January 2011 and 31 December 2012 were enrolled. Those who met the diagnostic criteria of acute cholangitis by TG13 were statistically analyzed. ResultsA total of 7,294 patients were enrolled and 6,433 patients met the TG13 diagnostic criteria. The severity distribution was Grade I (37.5%), Grade II (36.2%), and Grade III (26.2%). The 30-day all-cause mortality was 2.4%, 4.7%, and 8.4% in Grade I, II, III severity, respectively (P<0.001). The incidence of liver abscess and endocarditis as complications of acute cholangitis was 2.0% and 0.26%, respectively. ConclusionsThis is the first large scale study to investigate patients with acute cholangitis. This study provides the basis to define the best practices to manage patients with acute cholangitis in future studies.

引用

页码：310 / 318

页数：9

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