Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

被引：62

作者：

Benson, Robert A. ^{[1
]}

MacLeod, Megan K. L. ^{[1
]}

Hale, Benjamin G. ^{[2
]}

Patakas, Agapitos ^{[1
]}

Garside, Paul ^{[1
]}

Brewer, James M. ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland

[2] Univ Zurich, Inst Med Virol, Zurich, Switzerland

来源：

ELIFE | 2015年 / 4卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

GERMINAL CENTER B; LYMPH-NODES; DENDRITIC CELLS; PARTICULATE VACCINES; IMMUNE-RESPONSE; TRANSGENIC MICE; INDUCTION; DIFFERENTIATION; ACTIVATION; INFLUENZA;

D O I：

10.7554/eLife.06994

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses were associated with prolonged antigen presentation by dendritic cells (DCs), which maintained T cell/DC interactions into stage 3 (>72 hr) of activation. Blocking stage 3 interactions ablated Tfh generation, demonstrating a causal link between T cell-DC behaviour and functional outcomes. The current data therefore explain how duration of antigen presentation affects the dynamics of T cell-DC interactions and consequently determine Tfh cell differentiation in the developing immune response.

引用

页数：16

共 48 条

[21] The signalling imprints of nanoparticle uptake by bone marrow derived dendritic cells [J].

Karlson, Tanya De L. ;

Kong, Ying Ying ;

Hardy, Charles L. ;

Xiang, Sue Dong ;

Plebanski, Magdalena .

METHODS, 2013, 60 (03) :275-283

[22] Variation and infectivity neutralization in influenza [J].

Knossow, Marcel ;

Skehel, John J. .

IMMUNOLOGY, 2006, 119 (01) :1-7

[23] Visualizing dendritic cell networks in vivo [J].

Lindquist, RL ;

Shakhar, G ;

Dudziak, D ;

Wardemann, H ;

Eisenreich, T ;

Dustin, ML ;

Nussenzweig, MC .

NATURE IMMUNOLOGY, 2004, 5 (12) :1243-1250

[24] Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos [J].

Linterman, Michelle A. ;

Rigby, Robert J. ;

Wong, Raphael ;

Silva, Diego ;

Withers, David ;

Anderson, Graham ;

Verma, Naresh K. ;

Brink, Robert ;

Hutloff, Andreas ;

Goodnow, Chris C. ;

Vinuesa, Carola G. .

IMMUNITY, 2009, 30 (02) :228-241

[25] The origins, function, and regulation of T follicular helper cells [J].

Ma, Cindy S. ;

Deenick, Elissa K. ;

Batten, Marcel ;

Tangye, Stuart G. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (07) :1241-1253

[26] Nanoparticles target distinct dendritic cell populations according to their size [J].

Manolova, Vania ;

Flace, Anna ;

Bauer, Monika ;

Schwarz, Katrin ;

Saudan, Philippe ;

Bachmann, Martin F. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (05) :1404-1413

[27] DEVELOPMENT AND FOLLICULAR LOCALIZATION OF TOLERANT LYMPHOCYTES-B IN LYSOZYME ANTILYSOZYME IGM IGD TRANSGENIC MICE [J].

MASON, DY ;

JONES, M ;

GOODNOW, CC .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (02) :163-175

[28] T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases [J].

Mempel, TR ;

Henrickson, SE ;

von Andrian, UH .

NATURE, 2004, 427 (6970) :154-159

[29] Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes [J].

Miller, MJ ;

Safrina, O ;

Parker, I ;

Cahalan, MD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (07) :847-856

[30] Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction [J].

Moon, James J. ;

Suh, Heikyung ;

Li, Adrienne V. ;

Ockenhouse, Christian F. ;

Yadava, Anjali ;

Irvine, Darrell J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (04) :1080-1085

← 1 2 3 4 5 →