Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

被引：61

作者：

Benson, Robert A. ^{[1
]}

MacLeod, Megan K. L. ^{[1
]}

Hale, Benjamin G. ^{[2
]}

Patakas, Agapitos ^{[1
]}

Garside, Paul ^{[1
]}

Brewer, James M. ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland

[2] Univ Zurich, Inst Med Virol, Zurich, Switzerland

来源：

ELIFE | 2015年 / 4卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

GERMINAL CENTER B; LYMPH-NODES; DENDRITIC CELLS; PARTICULATE VACCINES; IMMUNE-RESPONSE; TRANSGENIC MICE; INDUCTION; DIFFERENTIATION; ACTIVATION; INFLUENZA;

D O I：

10.7554/eLife.06994

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses were associated with prolonged antigen presentation by dendritic cells (DCs), which maintained T cell/DC interactions into stage 3 (>72 hr) of activation. Blocking stage 3 interactions ablated Tfh generation, demonstrating a causal link between T cell-DC behaviour and functional outcomes. The current data therefore explain how duration of antigen presentation affects the dynamics of T cell-DC interactions and consequently determine Tfh cell differentiation in the developing immune response.

引用

页数：16

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