In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach

被引：17

作者：

Dieckhoff, J. ^{[1
]}

Kaul, M. G. ^{[1
]}

Mummert, T. ^{[1
]}

Jung, C. ^{[1
]}

Salamon, J. ^{[1
]}

Adam, G. ^{[1
]}

Knopp, T. ^{[2
,3
]}

Ludwig, F. ^{[4
]}

Balceris, C. ^{[4
]}

Ittrich, H. ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol & Nucl Med, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Sect Biomed Imaging, D-20246 Hamburg, Germany

[3] Hamburg Univ Technol, Inst Biomed Imaging, D-21073 Hamburg, Germany

[4] TU Braunschweig, Inst Elect Measurement & Fundamental Elect Engn, D-38106 Braunschweig, Germany

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2017年 / 62卷 / 09期

关键词：

magnetic particle imaging; liver imaging; iron oxide contrast agent; magnetorelaxometry; magnetic particle spectroscopy; SENSITIVITY; BIODISTRIBUTION; SYSTEM; MRI;

D O I：

10.1088/1361-6560/aa562d

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Magnetic particle imaging (MPI) facilitates the rapid determination of 3D in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist((R))) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique. For instance, similar results were obtained between ferucarbotran embedded in freeze-dried mannitol sugar and liver tissue harvested after a ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data enlarged the field of view and increased the covering of liver MPI on magnetic resonance images noticeably.

引用

页码：3470 / 3482

页数：13

共 28 条

[1] Quantitative "Hot-Spot" Imaging of Transplanted Stem Cells Using Superparamagnetic Tracers and Magnetic Particle Imaging [J].