Effect of combined use of a low-carbohydrate, high-protein diet with omega-3 polyunsaturated fatty acid supplementation on glycemic control in newly diagnosed type 2 diabetes: a randomized, double-blind, parallel-controlled trial

被引:23
作者
Liu, Kai [1 ,2 ]
Wang, Bin [1 ,3 ,4 ]
Zhou, Rui [1 ]
Lang, He-Dong [1 ]
Ran, Li [1 ]
Wang, Jian [1 ,5 ]
Li, Ling [6 ]
Kang, Chao [1 ]
Zhu, Xiao-Hui [1 ]
Zhang, Qian-Yong [1 ]
Zhu, Jun-Dong [1 ]
Doucette, Steve [7 ]
Kang, Jing X. [3 ,4 ]
Mi, Man-Tian [1 ]
机构
[1] Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing Key Lab Nutr & Food Safety,Chongqing Me, Chongqing, Peoples R China
[2] Ctr Dis Control & Prevent, Shenyang Joint Logist Support Ctr, Dept Hlth Supervis, Shenyang, Liaoning, Peoples R China
[3] Massachusetts Gen Hosp, Lab Lipid Med & Technol, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02115 USA
[5] Third Mil Med Univ, Xinqiao Hosp, Dept Clin Nutr, Chongqing, Peoples R China
[6] Third Mil Med Univ, Southwest Hosp, Dept Hlth Ctr, Chongqing, Peoples R China
[7] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada
基金
中国国家自然科学基金;
关键词
glycemic control; low-carbohydrate; high-protein diet; omega-3 PUFA supplementation; type; 2; diabetes; INSULIN SENSITIVITY; GLUCOSE; MANAGEMENT; N-3; IMPROVES; OVERWEIGHT; PREVENTION; RESISTANCE; INGESTION; DISEASES;
D O I
10.1093/ajcn/nqy120
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The combined effect of a low-carbohydrate, high-protein (LCHP) diet and omega-3(n-3) polyunsaturated fatty acid (PUFA) supplementation on patients with type 2 diabetes (T2D) is not known. Objective: The aim of this study was to evaluate the effect of an LCHP diet combined with omega-3 (LCHP+omega-3) on glycemic control in patients with T2D. Design: In this randomized, double-blind, parallel-controlled trial, 122 newly diagnosed participants with T2D were randomly assigned to receive a high-carbohydrate, low-protein diet with low omega-3 PUFAs [control (CON)], an LCHP, omega-3, or LCHP+omega-3 diet for 12 wk. The ratio of carbohydrate to protein was 42:28 in the LCHP and LCHP+omega-3 diet and 54:17 in the CON and omega-3 diet. The participants were given 6 g fish oil/d (containing 3.65 g docosahexaenoic acid, eicosapentaenoic acid, and docosapentaenoic acid/d) in the omega-3 and LCHP+omega-3 diet groups or 6 g corn oil/d (placebo) in the CON and LCHP diet groups. Results: Compared with the CON diet group, greater decreases in glycated hemoglobin (HbA1c) and fasting glucose were observed in all of the other 3 diet groups at 12 wk. Of note, HbA1c reduction in the LCHP+omega-3 diet group (-0.51%; 95% CI: -0.64%, -0.37%) was greater than that in the LCHP (P = 0.03) and omega-3 (P = 0.01) diet groups at 12 wk. In terms of fasting glucose, only the LCHP+omega-3 diet group showed a significant decrease at 4 wk (P = 0.03 compared with CON). Moreover, the reduction in fasting glucose in the LCHP+omega-3 diet group (-1.32 mmol/L; 95% CI: -1.72, -0.93 mmol/L) was greater than that in the LCHP (P = 0.04) and omega-3 (P = 0.03) diet groups at 12 wk. Conclusions: The LCHP+omega-3 diet provided greater effects on HbA1c and fasting glucose and faster effects on fasting glucose than both the LCHP and omega-3 diets, indicating the potential necessity of combining an LCHP diet with omega-3 PUFAs in T2D control.
引用
收藏
页码:256 / 265
页数:10
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