Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus?

被引：35

作者：

Demir, Nihat ^{[1
]}

Peker, Erdal ^{[1
]}

Ece, Ibrahim ^{[2
]}

Agengin, Kemal ^{[3
]}

Bulan, Keziban Asli ^{[4
]}

Tuncer, Oguz ^{[1
]}

机构：

[1] Yuzuncu Yil Univ, Sch Med, Div Neonatol, Dept Pediat, Van, Turkey

[2] Yuzuncu Yil Univ, Sch Med, Div Cardiol, Dept Pediat, Van, Turkey

[3] Yuzuncu Yil Univ, Sch Med, Dept Pediat Surg, Van, Turkey

[4] Yuzuncu Yil Univ, Sch Med, Dept Pediat, Div Endocrinol, Van, Turkey

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2016年 / 29卷 / 12期

关键词：

Ductus arteriosus; platelet count; platelet mass; preterm newborn; PRETERM INFANTS; VOLUME; THROMBOCYTOPENIA; CONTRIBUTE; MECHANISMS;

D O I：

10.3109/14767058.2015.1067296

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: The purpose of this study was to evaluate whether or not platelet mass contributes to closure of patent ductus arteriosus (PDA) in premature newborns.Study design and subjects: This retrospective study included 115 preterm newborns with hemodynamically significant PDA (hPDA) and 120 newborns without PDA. The newborns' platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) were noted from their files and the platelet mass (platelet count plus MPV/10(3)) was calculated. Patients with congenital abnormality, persistent pulmonary hypertension or sepsis were not included in the study.Results: Platelet count and PDW were found to not be risk factors for closure of hPDA (p>0.05), but both high platelet mass (OR 1.25; 95% CI 1.12-1.41) and MPV (OR 1.87; 95% CI 2.52-3.85) were determined to be independent risk factors for hPDA.Conclusions: Platelet mass may be a more significant indicator than platelet count of closure of hPDA in preterm newborns.

引用

页码：1915 / 1918

页数：4

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