Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle

被引：25

作者：

Castela, Mathieu ^{[1
,2
]}

Linay, Fabien ^{[1
,2
]}

Roy, Edwige ^{[1
,2
,3
]}

Moguelet, Philippe ^{[4
]}

Xu, Jie ^{[1
,2
]}

Holzenberger, Martin ^{[1
,2
]}

Khosrotehrani, Kiarash ^{[3
]}

Aractingi, Selim ^{[1
,5
,6
]}

机构：

[1] St Antoine Res Ctr, INSERM UMRS 938, Paris, France

[2] UPMC Univ Paris 6, Paris, France

[3] Univ Queensland, Expt Dermatol Grp, UQ Ctr Clin Res, Brisbane, Qld, Australia

[4] Hop Tenon, AP HP, Dept Pathol, Paris, France

[5] Univ Paris 5 Descartes, Paris, France

[6] Hop Cochin, AP HP, Dept Dermatol, Paris, France

来源：

EXPERIMENTAL DERMATOLOGY | 2017年 / 26卷 / 09期

关键词：

anagen; conditional gene targeting; hair cycle; Igf1r; stem cells; STEM-CELLS; FOLLICLE; GROWTH; INSULIN; KERATINOCYTES; DIFFERENTIATION; MAINTENANCE; EXPRESSION; ABLATION; NICHE;

D O I：

10.1111/exd.13287

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1rKO mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1r(KO) HFs entered anagen phase earlier than controls and showed a delay in the anagen/ catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1r(KO). MED1 transcription was impaired in the epidermis of K15-Igf1r(KO) mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation.

引用

页码：785 / 791

页数：7

共 34 条

[1] Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle [J].