Abnormal Mitochondrial Dynamics-A Novel Therapeutic Target for Alzheimer's Disease?

被引：61

作者：

Su, Bo ^{[1
]}

Wang, Xinglong ^{[1
]}

Bonda, David ^{[1
]}

Perry, Gorge ^{[1
,2
]}

Smith, Mark ^{[1
]}

Zhu, Xiongwei ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[2] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA

来源：

MOLECULAR NEUROBIOLOGY | 2010年 / 41卷 / 2-3期

关键词：

Alzheimer's disease; Mitochondrial dynamics; Mitochondrial fission; Mitochondrial fusion; Drug; Dimebon; DEPENDENT PROTEIN-KINASE; CASPASE-CLEAVED TAU; ALPHA-LIPOIC ACID; CALCIUM HOMEOSTASIS; AMYLOID-BETA; ENDOPLASMIC-RETICULUM; MISSENSE MUTATIONS; FUSION MEDIATORS; OXIDATIVE DAMAGE; ALTERED CALCIUM;

D O I：

10.1007/s12035-009-8095-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer's disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.

引用

页码：87 / 96

页数：10

共 149 条

[61] Hope in Alzheimer's fight emerges from unexpected places [J].

Gura, Trisha .

NATURE MEDICINE, 2008, 14 (09) :894-894

[62]

Hager K, 2007, J NEURAL TRANSM-SUPP, P189

[63] Alpha-lipoic acid as a new treatment option for Azheimer type dementia [J].

Hager, K ;

Marahrens, A ;

Kenklies, M ;

Riederer, P ;

Münch, G .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2001, 32 (03) :275-282

[64] Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria [J].

Hansson, CA ;

Frykman, S ;

Farmery, MR ;

Tjernberg, LO ;

Nilsberth, C ;

Pursglove, SE ;

Ito, A ;

Winblad, B ;

Cowburn, RF ;

Thyberg, J ;

Ankarcrona, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (49) :51654-51660

[65] Sumol conjugates and participates in mitochondrial substrates mitochondrial fission [J].

Harder, Z ;

Zunino, R ;

McBride, H .

CURRENT BIOLOGY, 2004, 14 (04) :340-345

[66] Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice [J].

Harris, FM ;

Brecht, WJ ;

Xu, Q ;

Tesseur, I ;

Kekonius, L ;

Wyss-Coray, T ;

Fish, JD ;

Masliah, E ;

Hopkins, PC ;

Scearce-Levie, K ;

Weisgraber, KH ;

Mucke, L ;

Mahley, RW ;

Huang, YD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10966-10971

[67] Mitochondrial abnormalities in Alzheimer's disease [J].

Hirai, K ;

Aliev, G ;

Nunomura, A ;

Fujioka, H ;

Russell, RL ;

Atwood, CS ;

Johnson, AB ;

Kress, Y ;

Vinters, HV ;

Tabaton, M ;

Shimohama, S ;

Cash, AD ;

Siedlak, SL ;

Harris, PLR ;

Jones, PK ;

Petersen, RB ;

Perry, G ;

Smith, MA .

JOURNAL OF NEUROSCIENCE, 2001, 21 (09) :3017-3023

[68] FINE-STRUCTURAL STUDY OF NEUROFIBRILLARY CHANGES IN A FAMILY WITH AMYOTROPHIC LATERAL SCLEROSIS [J].

HIRANO, A ;

NAKANO, I ;

KURLAND, LT ;

MULDER, DW ;

HOLLEY, PW ;

SACCOMANNO, G .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1984, 43 (05) :471-480

[69] Developing pharmacological therapies for Alzheimer disease [J].

Iqbal, K. ;

Grundke-Iqbal, I. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (17) :2234-2244

[70] Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity [J].

Ishihara, N ;

Eura, Y ;

Mihara, K .

JOURNAL OF CELL SCIENCE, 2004, 117 (26) :6535-6546

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