Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy

被引：26
作者：
Gu, Xing-Long
Sun, Yan-Gang
Yu, Long-Chuan [1 ]
机构：
[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Ctr Brain & Cognit Sci, Beijing 100871, Peoples R China
来源：
BEHAVIOURAL BRAIN RESEARCH | 2007年 / 179卷 / 02期
基金：
中国国家自然科学基金;
关键词：
antinociception; mononeuropathy; galanin; arcuate nucleus; hindpaw withdrawal latency;
D O I：
10.1016/j.bbr.2007.02.033
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulation increased significantly after intra-hypothalamic arcuate nucleus (ARC) injection of galanin in mononeuropathic rats, while intra-ARC injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The number of galaninergic neurons in the ARC increased in rats with mononeuropathy than that in normal rats. The results demonstrated that both endogenous and exogenous galanin were involved in the regulation of nociception in the ARC of rats with peripheral nerve injury. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：331 / 335
页数：5
相关论文
共 32 条
[1]   Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests [J].
Bartfai, T ;
Lu, XY ;
Badie-Mahdavi, H ;
Barr, AM ;
Mazarati, A ;
Hua, XY ;
Yaksh, T ;
Haberhauer, G ;
Ceide, SC ;
Trembleau, L ;
Somogyi, L ;
Kröck, L ;
Rebek, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10470-10475
[2]   A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].
BENNETT, GJ ;
XIE, YK .
PAIN, 1988, 33 (01) :87-107
[3]   Assessment of new functional roles for galanin in the CNS [J].
Brewer, A ;
Echevarria, DJ ;
Langel, Ü ;
Robinson, JK .
NEUROPEPTIDES, 2005, 39 (03) :323-326
[4]   The effect of a peripheral mononeuropathy on immunoreactive (ir)-galanin release in the spinal cord of the rat [J].
Colvin, LA ;
Mark, MA ;
Duggan, AW .
BRAIN RESEARCH, 1997, 766 (1-2) :259-261
[5]   In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states [J].
Flatters, SJL ;
Fox, AJ ;
Dickenson, AH .
NEUROSCIENCE, 2003, 116 (04) :1005-1012
[6]   Distribution, regulation and role of hypothalamic galanin systems: Renewed interest in a pleiotropic peptide family [J].
Gundlach, AL ;
Burazin, TCD ;
Larm, JA .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2001, 28 (1-2) :100-105
[7]   Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour [J].
Hobson, Sally-Ann ;
Holmes, Fiona E. ;
Kerr, Niall C. H. ;
Pope, Robert J. P. ;
Wynick, David .
JOURNAL OF NEUROCHEMISTRY, 2006, 99 (03) :1000-1010
[8]   Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury [J].
Holmes, FE ;
Mahoney, SA ;
Wynick, D .
NEUROPEPTIDES, 2005, 39 (03) :191-199
[9]   Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury [J].
Hygge-Blakeman, K ;
Brumovsky, P ;
Hao, JX ;
Xu, XJ ;
Hökfelt, T ;
Crawley, JN ;
Wiesenfeld-Hallin, Z .
BRAIN RESEARCH, 2004, 1025 (1-2) :152-158
[10]   Increase of galanin-like immunoreactivity in rat hypothalamic arcuate neurons after peripheral nerve injury [J].
Imbe, H ;
Abe, T ;
Okamoto, K ;
Sato, M ;
Ito, H ;
Kumabe, S ;
Senba, E .
NEUROSCIENCE LETTERS, 2004, 368 (01) :102-106
1234