Synthetic Studies on Acochlearine: Construction of the A/B/C/E/F Ring System

被引：9

作者：

Fujioka, Kosuke ^{[1
]}

Miyamoto, Naoya ^{[1
]}

Toya, Hiroki ^{[1
]}

Okano, Kentaro ^{[1
]}

Tokuyama, Hidetoshi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Aoba 6-3, Sendai, Miyagi 9808578, Japan

来源：

SYNLETT | 2016年 / 27卷 / 04期

关键词：

alkaloids; halogenation; lactams; domino reaction; Mannich reaction; C-H functionalization; ALPHA-PICOLINE-BORANE; DITERPENOID ALKALOIDS; TRANSANNULAR AZIRIDINATION; REDUCTIVE AMINATION; RACEMULSONINE; ALDEHYDES; EFFICIENT; KETONES; WATER; CORE;

D O I：

10.1055/s-0035-1560384

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic studies on acochlearine are described. The pentacyclic A/B/C/E/F ring system of acochlearine was constructed from a bicyclic enone via chemoselective reductive amination, one-pot bromination-intramolecular Mannich reaction cascade, and 6-electrocyclization.

引用

页码：621 / 625

页数：5

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