Key advances in mechanisms of asthma, allergy, and immunology in 2009

被引：37

作者：

Finkelman, Fred D. ^{[1
,2
,3
]}

Boyce, Joshua A. ^{[5
]}

Vercelli, Donata ^{[6
,7
,8
]}

Rothenberg, Marc E. ^{[4
]}

机构：

[1] Univ Cincinnati, Coll Med, Div Immunol, Dept Med, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Cincinnati Vet Affairs Med Ctr, Cincinnati, OH 45267 USA

[3] Cincinnati Childrens Hosp, Med Ctr, Div Immunobiol, Cincinnati, OH USA

[4] Cincinnati Childrens Hosp, Med Ctr, Div Clin Immunol & Allergy, Cincinnati, OH USA

[5] Harvard Univ, Sch Med, Dept Med, Div Rheumatol Allergy & Immunol,Brigham & Womens, Boston, MA USA

[6] Univ Arizona, Funct Genom Lab, Arizona Resp Ctr, Tucson, AZ USA

[7] Univ Arizona, Coll Med, Dept Cell Biol, Tucson, AZ USA

[8] Univ Arizona, Arizona Ctr Biol Complex Dis, Tucson, AZ USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 125卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Allergic conjunctivitis; allergic inflammation; anaphylaxis; asthma; asthma genetics; atopic dermatitis; eosinophils; food allergy; immediate hypersensitivity; mast cells; nasal polyposis; polymorphisms; AIRWAY INFLAMMATION; ATOPIC-DERMATITIS; LUNG-FUNCTION; SENSITIZATION; RISK; POLYMORPHISMS; DISEASE; MODELS; ECZEMA; CELLS;

D O I：

10.1016/j.jaci.2009.12.936

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis, and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here. (J Allergy Clin Immunol 2010;125:312-8.)

引用

页码：312 / 318

页数：7

共 45 条

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