Cloning, characterization, and expression analysis of mouse enamelysin

被引：23

作者：

Caterina, J

Shi, J

Sun, X

Qian, Q

Yamada, S

Liu, Y

Krakora, S

Bartlett, JD

Yamada, Y

Engler, JA

Birkedal-Hansen, H

Simmer, JP

机构：

[1] Natl Inst Dent & Craniofacial Res, Matrix Metalloprot Unit, Bethesda, MD 20892 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Pediat Dent, San Antonio, TX 78284 USA

[3] Natl Inst Dent & Craniofacial Res, Craniofacial Dev Biol & Regenerat Branch, Bethesda, MD 20892 USA

[4] Forsyth Inst, Dept Biomineralizat, Boston, MA 02115 USA

[5] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2000年 / 79卷 / 09期

关键词：

MMP-20; amelogenin; ameloblast; odontoblast;

D O I：

10.1177/00220345000790091001

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Enamelysin is a recently isolated member of the matrix metalloproteinase (MMP) family of extracellular matrix (ECM)-degrading enzymes. Here we describe the isolation and characterization of the mouse enamelysin cDNA. Expression of mouse enamelysin was detectable only in ameloblasts and odontoblasts of developing teeth. Characterization of mouse enamelysin demonstrated that it is highly conserved in both its sequence content and pattern of expression relative to the porcine, human, and bovine homologues previously described.

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页码：1697 / 1703

页数：7

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